Urinary beta 2-microglobulin: early indicator of high dose cisdiamminedichloroplatinum nephrotoxicity? Influence of furosemide

To evaluate the efficacy of beta 2-microglobulin as an indicator of cisplatinum nephrotoxicity, creatinine clearance and urinary beta 2-microglobulin were measured in 19 patients during 5 h after administration of a single dose of 80 mg/m2 cisplatinum. Eleven patients received furosemide as a concom...

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Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 1986, Vol.18 (3), p.276
Main Authors: de Gislain, C, Dumas, M, d'Athis, P, Lautissier, J L, Escousse, A, Guerrin, J
Format: Article
Language:English
Subjects:
beta 2-Microglobulin - urine
Cisplatin - administration & dosage
Cisplatin - adverse effects
Creatinine - urine
Furosemide - administration & dosage
Furosemide - pharmacology
Humans
Kidney - drug effects
Kidney Tubules - drug effects
Prognosis
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Summary:To evaluate the efficacy of beta 2-microglobulin as an indicator of cisplatinum nephrotoxicity, creatinine clearance and urinary beta 2-microglobulin were measured in 19 patients during 5 h after administration of a single dose of 80 mg/m2 cisplatinum. Eleven patients received furosemide as a concomitant therapy. Serum creatinine and beta 2-microglobulin remained unchanged. A decrease of creatinine clearance was observed. Urinary beta 2-microglobulin increased between 1 and 3 h after administration. This suggests transient tubular damage immediately after the treatment course. The concomitant administration of furosemide does not modify these results. However, patients who developed long-term nephrotoxicity had no early rise of urinary beta 2-microglobulin excretion; thus, it is not possible to predict cumulative nephrotoxicity by measuring beta 2-microglobulin immediately after the first course of high-dose cisplatinum.
ISSN:0344-5704
DOI:10.1007/BF00273402