First total syntheses of kanjone and its natural analogues

Kanjone (1), a bioactive furanoflavone and a potent biomolecule, was first isolated from Pongamia pinnata (L.). Herein, we have developed two approaches to synthesize kanjone as well as its natural analogues 6-methoxyisopongaglabol (2) and 6,3'-dimethoxy-[2″,3″:7,8]furanoflavone (3) starting fr...

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Bibliographic Details
Published in:Journal of asian natural products research 2023-03, Vol.25 (3), p.277-286
Main Authors: Wu, Min, Xu, Li-Jia, Li, Ying, Yu, Pei, Lu, Lan, Xie, Shi-Ting, He, Yu-Jiao, Dong, Hong-Bo
Format: Article
Language:English
Subjects:
Benzaldehyde
Biomolecules
furanoflavone
kanjone
natural product
Total synthesis
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Summary:Kanjone (1), a bioactive furanoflavone and a potent biomolecule, was first isolated from Pongamia pinnata (L.). Herein, we have developed two approaches to synthesize kanjone as well as its natural analogues 6-methoxyisopongaglabol (2) and 6,3'-dimethoxy-[2″,3″:7,8]furanoflavone (3) starting from khellin and 3-hydroxy-4-methoxy-benzaldehyde, respectively.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2022.2065266