Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-]pyrimidines as potential anti-chikungunya agents

Convergent and convenient regioselective synthesis of novel thiazolo[2,3- a ]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals...

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Bibliographic Details
Published in:RSC advances 2020-01, Vol.1 (9), p.5191-5195
Main Authors: Fares, Mohamed, McCosker, Patrick M, Alsherbiny, Muhammad A, Willis, Anthony C, Clark, Timothy, Neyts, Johan, Jochmans, Dirk, Keller, Paul A
Format: Article
Language:English
Subjects:
Acetic acid
Aldehydes
Chemistry
Chikungunya virus
Convergence
Crystallography
Pyrimidines
Regioselectivity
Sodium acetate
Synthesis
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Summary:Convergent and convenient regioselective synthesis of novel thiazolo[2,3- a ]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present. Convergent and convenient regioselective synthesis of novel thiazolo[2,3- a ]pyrimidines was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra00257g