Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR

A hyperpolarised-NMR acquisition approach that is sensitive to the process of glucose-6-phosphate anomerization is presented. Using selective depolarisation of one of the anomer's signals, it is possible to observe the replenishing of this signal due to the fast anomeric exchange of this compou...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2020-11, Vol.1 (67), p.41197-4121
Main Authors: Uppala, Sivaranjan, Gamliel, Ayelet, Sapir, Gal, Sosna, Jacob, Gomori, J. Moshe, Katz-Brull, Rachel
Format: Article
Language:English
Subjects:
Chemistry
Depolarization
Exchanging
Glucose
NMR
Nuclear magnetic resonance
Rate constants
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A hyperpolarised-NMR acquisition approach that is sensitive to the process of glucose-6-phosphate anomerization is presented. Using selective depolarisation of one of the anomer's signals, it is possible to observe the replenishing of this signal due to the fast anomeric exchange of this compound. The forward to reverse reaction rate constants ratio was ca. 1.6. A hyperpolarised-NMR acquisition approach that is sensitive to the process of glucose-6-phosphate anomerization is presented.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra08022e