Applications of Friedel-Crafts reactions in total synthesis of natural products

Over the years, Friedel-Crafts (FC) reactions have been acknowledged as the most useful and powerful synthetic tools for the construction of a special kind of carbon-carbon bond involving an aromatic moiety. Its stoichiometric and, more recently, its catalytic procedures have extensively been studie...

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Bibliographic Details
Published in:RSC advances 2018-01, Vol.8 (7), p.461-4163
Main Authors: Heravi, Majid M, Zadsirjan, Vahideh, Saedi, Pegah, Momeni, Tayebeh
Format: Article
Language:English
Subjects:
Biological properties
Carbon
Catalysis
Chemical synthesis
Chemistry
Friedel-Crafts reaction
Natural products
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Summary:Over the years, Friedel-Crafts (FC) reactions have been acknowledged as the most useful and powerful synthetic tools for the construction of a special kind of carbon-carbon bond involving an aromatic moiety. Its stoichiometric and, more recently, its catalytic procedures have extensively been studied. This reaction in recent years has frequently been used as a key step (steps) in the total synthesis of natural products and targeted complex bioactive molecules. In this review, we try to underscore the applications of intermolecular and intramolecular FC reactions in the total syntheses of natural products and complex molecules, exhibiting diverse biological properties. In this review, we try to underscore the applications of intermolecular and intramolecular FC reactions in the total syntheses of natural products and complex molecules, exhibiting diverse biological properties.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra07325b