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Effects of Blood Pressure According to Age on End-Stage Renal Disease Development in Patients With Patients With Diabetes: A Nationwide Population-Based Cohort Study

Recent hypertension guidelines have recommended lower blood pressure (BP) targets in high-risk patients. However, there are no specific guidelines based on age or systolic and diastolic blood pressure (SBP and DBP, respectively). We aimed to assess the effects of age-related BP on development of end...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2022-05, p.101161HYPERTENSIONAHA12118881
Main Authors: Hui Bae, Eun, Yeob Lim, Sang, Kim, Bongseong, Ryom Oh, Tae, Hyun Song, Su, Heon Suh, Sang, Sang Choi, Hong, Mi Yang, Eun, Seong Kim, Chang, Kwon Ma, Seong, Han, Kyung-Do, Kim, Soo Wan
Format: Article
Language:English
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Summary:Recent hypertension guidelines have recommended lower blood pressure (BP) targets in high-risk patients. However, there are no specific guidelines based on age or systolic and diastolic blood pressure (SBP and DBP, respectively). We aimed to assess the effects of age-related BP on development of end-stage renal disease (ESRD) in patients with diabetes. A total of 2 563 870 patients with diabetes aged >20 years were selected from the Korean National Health Screening Program from 2009 to 2012 and followed up until the end of 2019. Participants were categorized into age and BP groups, and the hazard ratios for ESRD were calculated. During a median follow-up of 7.15 years, the incidence rates of ESRD increased with increasing SBP and DBP. The hazard ratio for ESRD was the highest in patients younger than 40 years of age with DBP≥100 mm Hg. The effect of SBP and DBP on ESRD development was attenuated with age (interaction was
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.121.18881