m 1 A RNA Modification in Gene Expression Regulation

-methyladenosine (m A) is a prevalent and reversible post-transcriptional RNA modification that decorates tRNA, rRNA and mRNA. Recent studies based on technical advances in analytical chemistry and high-throughput sequencing methods have revealed the crucial roles of m A RNA modification in gene reg...

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Bibliographic Details
Published in:Genes 2022-05, Vol.13 (5)
Main Authors: Jin, Hao, Huo, Chunxiao, Zhou, Tianhua, Xie, Shanshan
Format: Article
Language:English
Online Access:Get full text
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Summary:-methyladenosine (m A) is a prevalent and reversible post-transcriptional RNA modification that decorates tRNA, rRNA and mRNA. Recent studies based on technical advances in analytical chemistry and high-throughput sequencing methods have revealed the crucial roles of m A RNA modification in gene regulation and biological processes. In this review, we focus on progress in the study of m A methyltransferases, m A demethylases and m A-dependent RNA-binding proteins and highlight the biological mechanisms and functions of m A RNA modification, as well as its association with human disease. We also summarize the current understanding of detection approaches for m A RNA modification.
ISSN:2073-4425
DOI:10.3390/genes13050910