Role of 18 F-FDG PET/CT in the diagnosis and management of patients with Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm that can involve multisystem organs. Positron emission tomography/computed tomography (PET/CT) has been widely used in tumor staging and efficacy evaluation. However, at present, there are few F-fluorodeoxyglucose (FDG) PET/CT s...

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Bibliographic Details
Published in:Quantitative imaging in medicine and surgery 2022-06, Vol.12 (6), p.3351
Main Authors: Luo, Zhe-Huang, Lu, Pu-Xuan, Qi, Wan-Lin, Liao, Feng-Xiang, Jin, Ai-Fang, Zen, Qing-Yun
Format: Article
Language:English
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Summary:Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm that can involve multisystem organs. Positron emission tomography/computed tomography (PET/CT) has been widely used in tumor staging and efficacy evaluation. However, at present, there are few F-fluorodeoxyglucose (FDG) PET/CT studies on LCH. This study aimed to explore the possible role of F-FDG PET/CT in the diagnosis and management of patients with LCH. F-FDG PET/CT images of 22 Chinese patients diagnosed with LCH on biopsy or surgery histopathology between January 2011 and December 2020 were retrospectively analyzed. The incidence of LCH in each system was assessed by a PET/CT scan. The imaging characteristics were analyzed semiquantitatively and qualitatively. The discrepancies between PET/CT and conventional imaging modalities were recorded. Evaluations of curative effect according to RECIST1.1 and PERCIST1.0 were compared using Fisher's exact chi-squared test, and P values
ISSN:2223-4292