Calcium and phosphorus co-doped carbon dots enhance osteogenic differentiation for calvarial defect repair in situ

Calvarial bone defect remains a clinical challenge due to the lack of efficient osteo-inductive agent. Herein, a novel calcium and phosphorus codoped carbon dot (Ca/P-CD) for bone regeneration was synthesized using phosphoethanolamine and calcium gluconate as precursors. The resultant Ca/P-CDs exhib...

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Bibliographic Details
Published in:Biomedical materials (Bristol) 2022-09, Vol.17 (5), p.55007
Main Authors: Wu, Lin, Wu, Yunchao, Jingjin, Liu, Liu, Suwan, Li, Qianzhe, Yang, Mengyu, Zhang, Miaomiao, Ji, Qing, Zhang, Feimin, Du, Fengyi
Format: Article
Language:English
Subjects:
Bone Regeneration
Calcium
calvarial defect
Carbon
carbon dots
Osteogenesis
Phosphorus
Quantum Dots
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Summary:Calvarial bone defect remains a clinical challenge due to the lack of efficient osteo-inductive agent. Herein, a novel calcium and phosphorus codoped carbon dot (Ca/P-CD) for bone regeneration was synthesized using phosphoethanolamine and calcium gluconate as precursors. The resultant Ca/P-CDs exhibited ultra-small size, stable excitation dependent emission spectra and favorable dispersibility in water. Moreover, Ca/P-CDs with good biocompatibility rapidly entered the cytoplasm through endocytosis and increased the expression of bone differentiation genes. After mixing with temperature-sensitive hydrogel, Ca/P-CDs were injected into calvarial defect and promoted the repair of bone injury. These Ca/P-CDs provide a new treatment method for the bone repair and should be expended the application in the biomedical fields.
ISSN:1748-6041
1748-605X
DOI:10.1088/1748-605X/ac812f