Relationship between Serum Levels of Selenium and Thyroid Cancer: A Systematic Review and Meta-Analysis

Thyroid cancer is one of the most malignant tumors and a serious threat to human health. Selenium (Se) is an essential trace element that is critical for thyroid function. Since the relationship between Se and thyroid cancer remains unclear, a meta-analysis was performed to clarify the relationship....

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Bibliographic Details
Published in:Nutrition and cancer 2023, Vol.75 (1), p.14-23
Main Authors: Hao, Runhua, Yu, Ping, Gui, Lanlan, Wang, Niannian, Pan, Da, Wang, Shaokang
Format: Article
Language:English
Subjects:
Cancer
Case-Control Studies
Health risks
Humans
Meta-analysis
Selenium
Serum levels
Systematic review
Thyroid
Thyroid cancer
Thyroid Neoplasms
Trace Elements
Tumors
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Summary:Thyroid cancer is one of the most malignant tumors and a serious threat to human health. Selenium (Se) is an essential trace element that is critical for thyroid function. Since the relationship between Se and thyroid cancer remains unclear, a meta-analysis was performed to clarify the relationship. A total of five databases (PubMed, Web of Science, Scopus, Embase and Cochrane library) were searched for case-control studies and cohort studies on serum levels of Se and thyroid cancer published up to 13 July 2022. Seven articles consisting of 10 case-control studies and comprised of 2,205 subjects met the inclusion criteria for meta-analysis. From the 10 selected studies, pooled analysis indicated that thyroid cancer patients had lower serum levels of Se than healthy controls [standardized mean difference = −1.25, 95% confidence interval = (−2.07, −0.44), P = 0.003]. Our meta-analysis supports a significant relationship between serum levels of Se and thyroid cancer.
ISSN:0163-5581
1532-7914
DOI:10.1080/01635581.2022.2115082