Diagnostic and Dosimetry Features of [ 64 Cu]CuCl 2 in High-Grade Paediatric Infiltrative Gliomas

Paediatric diffuse high-grade gliomas (PDHGG) are rare central nervous system neoplasms lacking effective therapeutic options. Molecular imaging of tumour metabolism might identify novel diagnostic/therapeutic targets. In this study, we evaluated the distribution and the dosimetry aspects of [ Cu]Cu...

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Published in:Molecular imaging and biology 2023-04, Vol.25 (2), p.391
Main Authors: Fiz, Francesco, Bottoni, Gianluca, Ugolini, Martina, Righi, Sergio, Cirone, Alessio, Garganese, Maria Carmen, Verrico, Antonio, Rossi, Andrea, Milanaccio, Claudia, Ramaglia, Antonia, Mastronuzzi, Angela, Abate, Massimo Eraldo, Cacchione, Antonella, Gandolfo, Carlo, Colafati, Giovanna Stefania, Garrè, Maria Luisa, Morana, Giovanni, Piccardo, Arnoldo
Format: Article
Language:English
Subjects:
Adolescent
Child
Copper
Copper Radioisotopes
Female
Glioma - pathology
Humans
Magnetic Resonance Imaging
Positron Emission Tomography Computed Tomography - methods
Positron-Emission Tomography - methods
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Summary:Paediatric diffuse high-grade gliomas (PDHGG) are rare central nervous system neoplasms lacking effective therapeutic options. Molecular imaging of tumour metabolism might identify novel diagnostic/therapeutic targets. In this study, we evaluated the distribution and the dosimetry aspects of [ Cu]CuCl in PDHGG subjects, as copper is a key element in cellular metabolism whose turnover may be increased in tumour cells. Paediatric patients with PDHGG were prospectively recruited. [ Cu]CuCl PET/CT was performed 1 h after tracer injection; if the scan was positive, it was repeated 24 and 72 h later. Lesion standardised uptake value (SUV) and target-to-background ratio (TBR) were calculated. Tumour and organ dosimetry were computed using the MIRD algorithm. Each patient underwent an MRI scan, including FLAIR, T2-weighted and post-contrast T1-weighted imaging. Ten patients were enrolled (median age 9, range 6-16 years, 6 females). Diagnoses were diffuse midline gliomas (n = 8, 5 of which with H3K27 alterations) and diffuse hemispheric gliomas (n = 2). Six patients had visible tracer uptake (SUV: 1.0 ± 0.6 TBR: 5 ± 3.1). [ Cu]CuCl accumulation was always concordant with MRI contrast enhancement and was higher in the presence of radiological signs of necrosis. SUV and TBR progressively increased on the 24- and 72-h acquisitions (p 
ISSN:1860-2002
DOI:10.1007/s11307-022-01769-3