Two new triterpenoid glycosides from Bacopa monnieri and their cytotoxic activity

Using combined chromatographic methods, two new triterpenoid glycosides, bacopasaponin K (1) and bacopasaponin L (2), along with eight known compounds, bacopaside IV (3), bacopaside VII (4), bacopasaponin E (5), bacoside A 3 (6), bacopasaponin F (7), bacopasaponin C (8), bacopaside I (9), and bacopa...

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Bibliographic Details
Published in:Natural product research 2024-04, Vol.38 (7), p.1120-1126
Main Authors: Yen, Duong Thi Hai, Cuc, Nguyen Thi, Tai, Bui Huu, Van Kiem, Phan, Hoang Duc, Manh, Nhiem, Nguyen Xuan, Cho, Su-Hyeon, Jeong, Sung Baek, Seo, Yohan, Park, SeonJu
Format: Article
Language:English
Subjects:
Antineoplastic Agents
Bacopa - chemistry
Bacopa monnieri
bacopasaponin
bacopasaponin K
bacopasaponin L
Cholecystokinin
Chromatography
Colon cancer
Cytotoxicity
Glycosides
Glycosides - pharmacology
Humans
Lung cancer
Magnetic Resonance Spectroscopy
NMR
Nuclear magnetic resonance
Plant Extracts - chemistry
Plant Extracts - pharmacology
Saponins - chemistry
Triterpenes - chemistry
triterpenoid glycoside
Triterpenoid glycosides
Two dimensional analysis
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Summary:Using combined chromatographic methods, two new triterpenoid glycosides, bacopasaponin K (1) and bacopasaponin L (2), along with eight known compounds, bacopaside IV (3), bacopaside VII (4), bacopasaponin E (5), bacoside A 3 (6), bacopasaponin F (7), bacopasaponin C (8), bacopaside I (9), and bacopaside II (10) were isolated from the methanol extract of the Bacopa monnieri. Their structures were elucidated by 1D-, 2D-NMR spectroscopic analysis, HR-ESI-MS and comparing with the NMR data reported in the literature. All these compounds were evaluated for their cytotoxic activity using the cell counting kit-8 (CCK-8) assay. Compounds 4, 6, 8, and 10 exhibited potential cytotoxic effects against human lung cancer cells (PC9) and human colon cancer cells (SW620).
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2132498