Regulatory effect of isovitexin on MAPK/NF-κB signal in mice with acute ulcerative colitis

The aim of this study was to investigate the anti-inflammatory effects and mechanism of isovitexin on ulcerative colitis mice and RAW264.7 cells. The results showed that isovitexin had strong antioxidant and anti-inflammatory effects, and could restore intestinal barrier integrity (p 

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Bibliographic Details
Published in:Journal of asian natural products research 2023-08, Vol.25 (8), p.765-782
Main Authors: Liu, Ming-Xiu, Li, Ting, Wang, Wei-Guang, Guo, Jing, Wang, Rui-Rui, He, Hong-Ping, Li, Shu-Quan, Li, Yan-Ping
Format: Article
Language:English
Subjects:
Inflammatory bowel diseases
Isovitexin
MAP kinase
MAPK/NF-κB signaling pathway
MyD88 protein
NF-κB protein
Signal transduction
TLR4 protein
Toll-like receptors
Ulcerative colitis
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Summary:The aim of this study was to investigate the anti-inflammatory effects and mechanism of isovitexin on ulcerative colitis mice and RAW264.7 cells. The results showed that isovitexin had strong antioxidant and anti-inflammatory effects, and could restore intestinal barrier integrity (p 
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2022.2142121