Neural signature of attention impairment in allergic asthma: an ERP study

Background Cognitive impairments are linked to poor treatment response and disease control in allergic asthma. However, there are no studies exploring attention-related functional brain alterations in allergic asthma. Here, we explore attention deficit and its association with clinical characteristi...

Full description

Saved in:
Bibliographic Details
Published in:International journal of neuroscience 2024-08, Vol.ahead-of-print (ahead-of-print), p.1-11
Main Authors: Gholami-Mahtaj, Leila, Mooziri, Morteza, Bamdad, Sobhan, Mikaili, Mohammad, Jamaati, Hamidreza, Raoufy, Mohammad Reza
Format: Article
Language:English
Subjects:
Adult
Allergic asthma
Asthma - complications
Asthma - physiopathology
attention
Attention - physiology
Attention Deficit Disorder with Hyperactivity - physiopathology
Electroencephalography
event-related potentials
Evoked Potentials - physiology
Female
Humans
lung function
Male
Middle Aged
psychiatric disorders
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Cognitive impairments are linked to poor treatment response and disease control in allergic asthma. However, there are no studies exploring attention-related functional brain alterations in allergic asthma. Here, we explore attention deficit and its association with clinical characteristics and common neuropsychiatric disorders in patients with allergic asthma. Methods We recruited 38 participants, equally distributed into healthy and asthma groups. Behavioral, neurophysiological, and lung function assessment tools were used in this study. Results Our behavioral data show that allergic asthma induces attention impairment. Additionally, the event-related potentials (ERP) analysis reveals that this attention deficit is associated with a disruption in cognitive processing capability in frontal brain areas. These behavioral and neurophysiological abnormalities were strongly correlated with disease severity and neuropsychiatric comorbidities of asthmatic patients. Conclusion Together, here we propose that disrupted neurophysiological responses in frontal brain areas might lead to attention impairments in patients with allergic asthma. These findings could help characterizing the neuro-pathophysiology of cognitive disorders in allergic asthma, possibly opening the way for development of novel treatment strategies.
ISSN:0020-7454
1563-5279
1563-5279
1543-5245
DOI:10.1080/00207454.2022.2151908