Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions

The integration of nanomaterials (NMs) into an ever-expanding number of daily used products has proven to be highly desirable in numerous industries and applications. Unfortunately, the same "nano" specific physicochemical properties, which make these materials attractive, may also contrib...

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Bibliographic Details
Published in:Journal of toxicology and environmental health. Part B, Critical reviews Critical reviews, 2023-01, Vol.26 (1), p.1-27
Main Authors: Sreedharan, Sreejesh, Zouganelis, Georgios, Drake, Samantha J, Tripathi, Gyanendra, Kermanizadeh, Ali
Format: Article
Language:English
Subjects:
Asthma
Chronic illnesses
Disease
Engineered nanomaterials
genotoxicity
Hazard assessment
Hazards
Health hazards
Health risks
Humans
inflammation
Liver
Liver diseases
Lung
Nanomaterials
Nanostructures - toxicity
Nanotechnology
Oxidative stress
Physicochemical properties
pre-existing disease
Preexisting Condition Coverage
Toxic diseases
Toxicity
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Summary:The integration of nanomaterials (NMs) into an ever-expanding number of daily used products has proven to be highly desirable in numerous industries and applications. Unfortunately, the same "nano" specific physicochemical properties, which make these materials attractive, may also contribute to hazards for individuals exposed to these materials. In 2021, it was estimated that 7 out of 10 deaths globally were accredited to chronic diseases, such as chronic liver disease, asthma, and cardiovascular-related illnesses. Crucially, it is also understood that a significant proportion of global populace numbering in the billions are currently living with a range of chronic undiagnosed health conditions. Due to the significant number of individuals affected, it is important that people suffering from chronic disease also be considered and incorporated in NM hazard assessment strategies. This review examined and analyzed the literature that focused on NM-induced adverse health effects in models which are representative of individuals exhibiting pre-existing medical conditions with focus on the pulmonary, cardiovascular, hepatic, gastrointestinal, and central nervous systems. The overall objective of this review was to outline available data, highlighting the important role of pre-existing disease in NM-induced toxicity with the aim of establishing a weight of evidence approach to inform the public on the potential hazards posed by NMs in both healthy and compromised persons in general population.
ISSN:1093-7404
1521-6950
DOI:10.1080/10937404.2022.2153456