Impaired executive functioning mediates the association between aging and deterministic sequence learning

• Published in: Aging, Neuropsychology, and Cognition Neuropsychology, and Cognition, 2024-03, Vol.31 (2), p.323-339
• Main Authors: Petok, Jessica R., Dang, Layla, Hammel, Beatrice
• Format: Article
• Language: English
• Subjects: Adult; Age differences; Aged; Aging - psychology; Chaining; Cognitive Dysfunction; Executive Function; Frontal functioning; Frontal Lobe; Humans; Learning; Neuropsychological Tests; Sequence learning
• ISSN: 1382-5585; 1744-4128; 1744-4128
• DOI: 10.1080/13825585.2022.2153789

Sensitivity to the fixed ordering of actions and events, or deterministic sequence learning, is an important skill throughout adulthood. Yet, it remains unclear whether age deficits in sequencing exist, and we lack a firm understanding of which factors might contribute to age-related impairments when they arise. Though debated, executive functioning, governed by the frontal lobe, may underlie age-related sequence learning deficits in older adults. The present study asked if age predicts errors in deterministic sequence learning across the older adult lifespan (ages 55-89), and whether executive functioning accounts for any age-related declines. Healthy older adults completed a comprehensive measure of frontal-based executive abilities as well as a deterministic sequence learning task that required the step-by-step acquisition of associations through trial-and-error feedback. Among those who met a performance-based criterion, increasing age was positively correlated with higher sequencing errors; however, this relationship was no longer significant after controlling for executive functioning. Moreover, frontal-based executive abilities mediated the relationship between age and sequence learning performance. These findings suggest that executive or frontal functioning may underlie age deficits in learning judgment-based, deterministic serial operations.