Percutaneous Electroosmosis of Berberine-Loaded Ca 2+ Crosslinked Gelatin/Alginate Mixed Hydrogel

Flexible conductive hydrogel has been driven by scientific breakthroughs and offers a wide variety of applications, including sensors, electronic skins, biomedicine, energy storage, etc. Based on the mixed-ion crosslinking method, gelatin and sodium alginate (Gel-Alg) composite hydrogels were succes...

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Bibliographic Details
Published in:Polymers 2022-11, Vol.14 (23)
Main Authors: Liu, Yinyin, Shen, Si, Wu, Yifang, Wang, Mengmeng, Cheng, Yongfeng, Xia, Hongmei, Jia, Ruoyang, Liu, Chang, Wang, Yu, Xia, Ying, Cheng, Xiaoman, Yue, Yan, Xie, Zili
Format: Article
Language:English
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Summary:Flexible conductive hydrogel has been driven by scientific breakthroughs and offers a wide variety of applications, including sensors, electronic skins, biomedicine, energy storage, etc. Based on the mixed-ion crosslinking method, gelatin and sodium alginate (Gel-Alg) composite hydrogels were successfully prepared using Ca crosslinking. The migration behavior of berberine hydrochloride (BBH) in the matrix network structure of Gel-Alg hydrogel with a certain pore size under an electric field was studied, and the transdermal effect of berberine hydrochloride under an electric field was also studied. The experimental results show that Gel-Alg has good flexibility and conductivity, and electrical stimulation can enhance the transdermal effect of drugs. Gel-Alg composite hydrogel may be a new material with potential application value in future biomedical directions.
ISSN:2073-4360