Bifunctional tetrazole-carboxylate ligand based Zn() complexes: synthesis and their excellent potential anticancer properties

Transition metal coordination complexes have provided cancer treatment with new insights to overcome the limitations of current chemotherapeutic agents. Utilization of bifunctional tetrazole-carboxylate ligands with Zn( ii ) obtained two self-assembled complexes [Zn(HL 1 )(bipy) 3/2 (H 2 O)]·CH 3 OH...

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Published in:RSC advances 2022-11, Vol.12 (52), p.3388-33815
Main Authors: Tan, Li-Tao, Shen, Ting-Xiao, Jiang, Jing-Yi, Zhong, Yu-Jie, Lin, Fang-Qi, Xue, Hong, Yao, Yu-Xin, Jiang, Xin, Shen, Lei, He, Xin
Format: Article
Language:English
Subjects:
Acetic acid
Anticancer properties
Benzene
Chemistry
Coordination compounds
Ligands
Nanoparticles
Self-assembly
Tetrazoles
Toxicity
Transition metals
Zinc
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Summary:Transition metal coordination complexes have provided cancer treatment with new insights to overcome the limitations of current chemotherapeutic agents. Utilization of bifunctional tetrazole-carboxylate ligands with Zn( ii ) obtained two self-assembled complexes [Zn(HL 1 )(bipy) 3/2 (H 2 O)]·CH 3 OH·4(H 2 O) ( 1 ) (H 3 L 1 = 1,3,5-tri(2-carboxymethyltetrazol-5-yl) benzene) and [Zn(L 2 ) 2 (H 2 O) 2 ] 2 ·2H 2 O ( 2 ) (HL 2 = (5-pyridin-3-yl-tetrazol-2-yl)-acetic acid). The X-ray diffraction results showed that the two complexes displayed a two-dimensional (2D) layer structure and a one-dimensional (1D) layer structure. Nanocoprecipitation with DSPE-PEG-2000 resulted in the formation of complex nanoparticles (NPS) with excellent water dispersion. In vitro CCK-8 assay indicated the two NPs exert high cytotoxicity and sensitivity and a low half-maximum inhibitory concentration (IC 50 ) towards HeLa than HepG2 cells. In addition, the cytotoxicity was also confirmed by live/dead co-stained experiments. The presented experimental results showed the 1 and 2 NPs were capable of inhibiting cell proliferation in vitro and may help design coordination complex-based anticancer candidates for cancer cells. Two Zn( ii ) complexes based on tetrazol were prepared. Nanoparticles of the complexes can inhibit the proliferation of cancer cells in vitro . This work provided a strategy on designing anticancer materials based on coordination complexes.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra04768c