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Bifunctional tetrazole-carboxylate ligand based Zn() complexes: synthesis and their excellent potential anticancer properties
Transition metal coordination complexes have provided cancer treatment with new insights to overcome the limitations of current chemotherapeutic agents. Utilization of bifunctional tetrazole-carboxylate ligands with Zn( ii ) obtained two self-assembled complexes [Zn(HL 1 )(bipy) 3/2 (H 2 O)]·CH 3 OH...
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| Published in: | RSC advances 2022-11, Vol.12 (52), p.3388-33815 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 33815 |
| container_issue | 52 |
| container_start_page | 3388 |
| container_title | RSC advances |
| container_volume | 12 |
| creator | Tan, Li-Tao Shen, Ting-Xiao Jiang, Jing-Yi Zhong, Yu-Jie Lin, Fang-Qi Xue, Hong Yao, Yu-Xin Jiang, Xin Shen, Lei He, Xin |
| description | Transition metal coordination complexes have provided cancer treatment with new insights to overcome the limitations of current chemotherapeutic agents. Utilization of bifunctional tetrazole-carboxylate ligands with Zn(
ii
) obtained two self-assembled complexes [Zn(HL
1
)(bipy)
3/2
(H
2
O)]·CH
3
OH·4(H
2
O) (
1
) (H
3
L
1
= 1,3,5-tri(2-carboxymethyltetrazol-5-yl) benzene) and [Zn(L
2
)
2
(H
2
O)
2
]
2
·2H
2
O (
2
) (HL
2
= (5-pyridin-3-yl-tetrazol-2-yl)-acetic acid). The X-ray diffraction results showed that the two complexes displayed a two-dimensional (2D) layer structure and a one-dimensional (1D) layer structure. Nanocoprecipitation with DSPE-PEG-2000 resulted in the formation of complex nanoparticles (NPS) with excellent water dispersion.
In vitro
CCK-8 assay indicated the two NPs exert high cytotoxicity and sensitivity and a low half-maximum inhibitory concentration (IC
50
) towards HeLa than HepG2 cells. In addition, the cytotoxicity was also confirmed by live/dead co-stained experiments. The presented experimental results showed the
1
and
2
NPs were capable of inhibiting cell proliferation
in vitro
and may help design coordination complex-based anticancer candidates for cancer cells.
Two Zn(
ii
) complexes based on tetrazol were prepared. Nanoparticles of the complexes can inhibit the proliferation of cancer cells
in vitro
. This work provided a strategy on designing anticancer materials based on coordination complexes. |
| doi_str_mv | 10.1039/d2ra04768c |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_36505687</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2753662991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c428t-c287bef4c628380927be655716e415a7531efd2f0529717bd549d596a5417b0f3</originalsourceid><addsrcrecordid>eNpdksFrFDEUxoMotrS9eFcCXlphNMkkmYkHoa5WhYIgevESMpk3bUp2Mk0yslvwf2-2W9dqLt97vB8fX_KC0DNKXlNSqzc9i4bwRrb2EdpnhMuKEakeP6j30FFKV6QcKSiT9Cnaq6UgQrbNPvr93g3zaLMLo_E4Q47mJniorIldWK29yYC9uzBjjzuToMc_x-MTbMNy8rCC9Ban9ZgvIbmEN0wpXcSwsuA9jBlPIRdxxdoUsWa0EPEUwwQxO0iH6MlgfIKjez1AP84-fl98rs6_fvqyOD2vLGdtrixrmw4GbiVr65YoVjopREMlcCpMI2oKQ88GIphqaNP1gqteKGkELx0Z6gP0bus7zd0SelsyReP1FN3SxLUOxul_J6O71Bfhl1ZS1YqKYnB8bxDD9Qwp66VLm0uaEcKcNCsZpGRK0YK-_A-9CnMsr7uhOK0p45IX6tWWsjGkFGHYhaFEbxarP7Bvp3eLXRT4xcP4O_TPGgvwfAvEZHfTvz-jvgXXy6ov</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2741312464</pqid></control><display><type>article</type><title>Bifunctional tetrazole-carboxylate ligand based Zn() complexes: synthesis and their excellent potential anticancer properties</title><source>PubMed (Medline)</source><creator>Tan, Li-Tao ; Shen, Ting-Xiao ; Jiang, Jing-Yi ; Zhong, Yu-Jie ; Lin, Fang-Qi ; Xue, Hong ; Yao, Yu-Xin ; Jiang, Xin ; Shen, Lei ; He, Xin</creator><creatorcontrib>Tan, Li-Tao ; Shen, Ting-Xiao ; Jiang, Jing-Yi ; Zhong, Yu-Jie ; Lin, Fang-Qi ; Xue, Hong ; Yao, Yu-Xin ; Jiang, Xin ; Shen, Lei ; He, Xin</creatorcontrib><description>Transition metal coordination complexes have provided cancer treatment with new insights to overcome the limitations of current chemotherapeutic agents. Utilization of bifunctional tetrazole-carboxylate ligands with Zn(
ii
) obtained two self-assembled complexes [Zn(HL
1
)(bipy)
3/2
(H
2
O)]·CH
3
OH·4(H
2
O) (
1
) (H
3
L
1
= 1,3,5-tri(2-carboxymethyltetrazol-5-yl) benzene) and [Zn(L
2
)
2
(H
2
O)
2
]
2
·2H
2
O (
2
) (HL
2
= (5-pyridin-3-yl-tetrazol-2-yl)-acetic acid). The X-ray diffraction results showed that the two complexes displayed a two-dimensional (2D) layer structure and a one-dimensional (1D) layer structure. Nanocoprecipitation with DSPE-PEG-2000 resulted in the formation of complex nanoparticles (NPS) with excellent water dispersion.
In vitro
CCK-8 assay indicated the two NPs exert high cytotoxicity and sensitivity and a low half-maximum inhibitory concentration (IC
50
) towards HeLa than HepG2 cells. In addition, the cytotoxicity was also confirmed by live/dead co-stained experiments. The presented experimental results showed the
1
and
2
NPs were capable of inhibiting cell proliferation
in vitro
and may help design coordination complex-based anticancer candidates for cancer cells.
Two Zn(
ii
) complexes based on tetrazol were prepared. Nanoparticles of the complexes can inhibit the proliferation of cancer cells
in vitro
. This work provided a strategy on designing anticancer materials based on coordination complexes.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/d2ra04768c</identifier><identifier>PMID: 36505687</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Acetic acid ; Anticancer properties ; Benzene ; Chemistry ; Coordination compounds ; Ligands ; Nanoparticles ; Self-assembly ; Tetrazoles ; Toxicity ; Transition metals ; Zinc</subject><ispartof>RSC advances, 2022-11, Vol.12 (52), p.3388-33815</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2022</rights><rights>This journal is © The Royal Society of Chemistry 2022 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-c287bef4c628380927be655716e415a7531efd2f0529717bd549d596a5417b0f3</citedby><cites>FETCH-LOGICAL-c428t-c287bef4c628380927be655716e415a7531efd2f0529717bd549d596a5417b0f3</cites><orcidid>0000-0002-3269-2254</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693915/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693915/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36505687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Li-Tao</creatorcontrib><creatorcontrib>Shen, Ting-Xiao</creatorcontrib><creatorcontrib>Jiang, Jing-Yi</creatorcontrib><creatorcontrib>Zhong, Yu-Jie</creatorcontrib><creatorcontrib>Lin, Fang-Qi</creatorcontrib><creatorcontrib>Xue, Hong</creatorcontrib><creatorcontrib>Yao, Yu-Xin</creatorcontrib><creatorcontrib>Jiang, Xin</creatorcontrib><creatorcontrib>Shen, Lei</creatorcontrib><creatorcontrib>He, Xin</creatorcontrib><title>Bifunctional tetrazole-carboxylate ligand based Zn() complexes: synthesis and their excellent potential anticancer properties</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>Transition metal coordination complexes have provided cancer treatment with new insights to overcome the limitations of current chemotherapeutic agents. Utilization of bifunctional tetrazole-carboxylate ligands with Zn(
ii
) obtained two self-assembled complexes [Zn(HL
1
)(bipy)
3/2
(H
2
O)]·CH
3
OH·4(H
2
O) (
1
) (H
3
L
1
= 1,3,5-tri(2-carboxymethyltetrazol-5-yl) benzene) and [Zn(L
2
)
2
(H
2
O)
2
]
2
·2H
2
O (
2
) (HL
2
= (5-pyridin-3-yl-tetrazol-2-yl)-acetic acid). The X-ray diffraction results showed that the two complexes displayed a two-dimensional (2D) layer structure and a one-dimensional (1D) layer structure. Nanocoprecipitation with DSPE-PEG-2000 resulted in the formation of complex nanoparticles (NPS) with excellent water dispersion.
In vitro
CCK-8 assay indicated the two NPs exert high cytotoxicity and sensitivity and a low half-maximum inhibitory concentration (IC
50
) towards HeLa than HepG2 cells. In addition, the cytotoxicity was also confirmed by live/dead co-stained experiments. The presented experimental results showed the
1
and
2
NPs were capable of inhibiting cell proliferation
in vitro
and may help design coordination complex-based anticancer candidates for cancer cells.
Two Zn(
ii
) complexes based on tetrazol were prepared. Nanoparticles of the complexes can inhibit the proliferation of cancer cells
in vitro
. This work provided a strategy on designing anticancer materials based on coordination complexes.</description><subject>Acetic acid</subject><subject>Anticancer properties</subject><subject>Benzene</subject><subject>Chemistry</subject><subject>Coordination compounds</subject><subject>Ligands</subject><subject>Nanoparticles</subject><subject>Self-assembly</subject><subject>Tetrazoles</subject><subject>Toxicity</subject><subject>Transition metals</subject><subject>Zinc</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdksFrFDEUxoMotrS9eFcCXlphNMkkmYkHoa5WhYIgevESMpk3bUp2Mk0yslvwf2-2W9dqLt97vB8fX_KC0DNKXlNSqzc9i4bwRrb2EdpnhMuKEakeP6j30FFKV6QcKSiT9Cnaq6UgQrbNPvr93g3zaLMLo_E4Q47mJniorIldWK29yYC9uzBjjzuToMc_x-MTbMNy8rCC9Ban9ZgvIbmEN0wpXcSwsuA9jBlPIRdxxdoUsWa0EPEUwwQxO0iH6MlgfIKjez1AP84-fl98rs6_fvqyOD2vLGdtrixrmw4GbiVr65YoVjopREMlcCpMI2oKQ88GIphqaNP1gqteKGkELx0Z6gP0bus7zd0SelsyReP1FN3SxLUOxul_J6O71Bfhl1ZS1YqKYnB8bxDD9Qwp66VLm0uaEcKcNCsZpGRK0YK-_A-9CnMsr7uhOK0p45IX6tWWsjGkFGHYhaFEbxarP7Bvp3eLXRT4xcP4O_TPGgvwfAvEZHfTvz-jvgXXy6ov</recordid><startdate>20221122</startdate><enddate>20221122</enddate><creator>Tan, Li-Tao</creator><creator>Shen, Ting-Xiao</creator><creator>Jiang, Jing-Yi</creator><creator>Zhong, Yu-Jie</creator><creator>Lin, Fang-Qi</creator><creator>Xue, Hong</creator><creator>Yao, Yu-Xin</creator><creator>Jiang, Xin</creator><creator>Shen, Lei</creator><creator>He, Xin</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3269-2254</orcidid></search><sort><creationdate>20221122</creationdate><title>Bifunctional tetrazole-carboxylate ligand based Zn() complexes: synthesis and their excellent potential anticancer properties</title><author>Tan, Li-Tao ; Shen, Ting-Xiao ; Jiang, Jing-Yi ; Zhong, Yu-Jie ; Lin, Fang-Qi ; Xue, Hong ; Yao, Yu-Xin ; Jiang, Xin ; Shen, Lei ; He, Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-c287bef4c628380927be655716e415a7531efd2f0529717bd549d596a5417b0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acetic acid</topic><topic>Anticancer properties</topic><topic>Benzene</topic><topic>Chemistry</topic><topic>Coordination compounds</topic><topic>Ligands</topic><topic>Nanoparticles</topic><topic>Self-assembly</topic><topic>Tetrazoles</topic><topic>Toxicity</topic><topic>Transition metals</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Li-Tao</creatorcontrib><creatorcontrib>Shen, Ting-Xiao</creatorcontrib><creatorcontrib>Jiang, Jing-Yi</creatorcontrib><creatorcontrib>Zhong, Yu-Jie</creatorcontrib><creatorcontrib>Lin, Fang-Qi</creatorcontrib><creatorcontrib>Xue, Hong</creatorcontrib><creatorcontrib>Yao, Yu-Xin</creatorcontrib><creatorcontrib>Jiang, Xin</creatorcontrib><creatorcontrib>Shen, Lei</creatorcontrib><creatorcontrib>He, Xin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Li-Tao</au><au>Shen, Ting-Xiao</au><au>Jiang, Jing-Yi</au><au>Zhong, Yu-Jie</au><au>Lin, Fang-Qi</au><au>Xue, Hong</au><au>Yao, Yu-Xin</au><au>Jiang, Xin</au><au>Shen, Lei</au><au>He, Xin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bifunctional tetrazole-carboxylate ligand based Zn() complexes: synthesis and their excellent potential anticancer properties</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2022-11-22</date><risdate>2022</risdate><volume>12</volume><issue>52</issue><spage>3388</spage><epage>33815</epage><pages>3388-33815</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Transition metal coordination complexes have provided cancer treatment with new insights to overcome the limitations of current chemotherapeutic agents. Utilization of bifunctional tetrazole-carboxylate ligands with Zn(
ii
) obtained two self-assembled complexes [Zn(HL
1
)(bipy)
3/2
(H
2
O)]·CH
3
OH·4(H
2
O) (
1
) (H
3
L
1
= 1,3,5-tri(2-carboxymethyltetrazol-5-yl) benzene) and [Zn(L
2
)
2
(H
2
O)
2
]
2
·2H
2
O (
2
) (HL
2
= (5-pyridin-3-yl-tetrazol-2-yl)-acetic acid). The X-ray diffraction results showed that the two complexes displayed a two-dimensional (2D) layer structure and a one-dimensional (1D) layer structure. Nanocoprecipitation with DSPE-PEG-2000 resulted in the formation of complex nanoparticles (NPS) with excellent water dispersion.
In vitro
CCK-8 assay indicated the two NPs exert high cytotoxicity and sensitivity and a low half-maximum inhibitory concentration (IC
50
) towards HeLa than HepG2 cells. In addition, the cytotoxicity was also confirmed by live/dead co-stained experiments. The presented experimental results showed the
1
and
2
NPs were capable of inhibiting cell proliferation
in vitro
and may help design coordination complex-based anticancer candidates for cancer cells.
Two Zn(
ii
) complexes based on tetrazol were prepared. Nanoparticles of the complexes can inhibit the proliferation of cancer cells
in vitro
. This work provided a strategy on designing anticancer materials based on coordination complexes.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>36505687</pmid><doi>10.1039/d2ra04768c</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3269-2254</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2046-2069 |
| ispartof | RSC advances, 2022-11, Vol.12 (52), p.3388-33815 |
| issn | 2046-2069 2046-2069 |
| language | eng |
| recordid | cdi_pubmed_primary_36505687 |
| source | PubMed (Medline) |
| subjects | Acetic acid Anticancer properties Benzene Chemistry Coordination compounds Ligands Nanoparticles Self-assembly Tetrazoles Toxicity Transition metals Zinc |
| title | Bifunctional tetrazole-carboxylate ligand based Zn() complexes: synthesis and their excellent potential anticancer properties |
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