Improved hemophagocytic lymphohistiocytosis index predicts prognosis of adult Epstein-Barr virus-associated HLH patients

Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a common subtype of HLH with heterogeneous clinical presentations from self-limited to death, of which adults are worse than children. To establish predictors of mortality risk in adult EBV-HLH patients for timely an...

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Bibliographic Details
Published in:Annals of medicine (Helsinki) 2023-12, Vol.55 (1), p.89-100
Main Authors: Yao, Shuyan, He, Lingbo, Zhang, Ruoxi, Liu, Menghan, Hua, Zhengjie, Zou, Heshan, Wang, Zhao, Wang, Yini
Format: Article
Language:English
Subjects:
Adult
Child
EBV-associated hemophagocytic lymphohistiocytosis
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - drug therapy
Hematology
Herpesvirus 4, Human
HScore
Humans
improved hemophagocytic lymphohistiocytosis index
improved HLH criteria
Lymphohistiocytosis, Hemophagocytic - complications
Lymphohistiocytosis, Hemophagocytic - drug therapy
Prognosis
Retrospective Studies
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Summary:Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a common subtype of HLH with heterogeneous clinical presentations from self-limited to death, of which adults are worse than children. To establish predictors of mortality risk in adult EBV-HLH patients for timely and appropriate treatment. Patients with confirmed EBV-HLH admitted to Beijing Friendship Hospital from January 2015 to December 2019 were enrolled and statistical analysis of their laboratory test results was performed. Among 246 adult patients with EBV-HLH, the deceased were older (p 
ISSN:0785-3890
1365-2060
DOI:10.1080/07853890.2022.2149850