Risk assessment of hexachlorobutadiene (HCBD) in the Korean diet

Hexachlorobutadiene (HCBD) is a persistent organic pollutant (POP), and a toxin whose primary target organ is the kidney. Consequently, quantifying the amount of HCBD in food is essential for determining whether it poses a health risk. The current study established and validated an analytical method...

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Bibliographic Details
Published in:Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Chemistry, analysis, control, exposure & risk assessment, 2023-02, Vol.40 (2), p.271-281
Main Authors: Junghyuck, Suh, Shin, Yongwoon, Lee, Jieun, Hakseung, Ryu, Seo, Sujin, Lee, Gunyoung, Koo, Yong Eui
Format: Article
Language:English
Subjects:
Agricultural products
Agriculture
Animal products
Animals
Body weight
Butadienes
Contamination
Diet
Fisheries
Fishery products
Food
Food consumption
Food Contamination - analysis
Food processing
Food products
Gas chromatography
Health risks
hexachlorobutadiene (HCBD)
Humans
Kidneys
Mass spectrometry
Mass spectroscopy
monitoring
Pharmacovigilance
POPs
Processed foods
Risk Assessment
Toxins
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Summary:Hexachlorobutadiene (HCBD) is a persistent organic pollutant (POP), and a toxin whose primary target organ is the kidney. Consequently, quantifying the amount of HCBD in food is essential for determining whether it poses a health risk. The current study established and validated an analytical method for assessing HCBD in food using gas chromatography/mass spectrometry (GC/MS). Subsequently, we conducted for the first time a risk assessment of HCBD through Korean food consumption. The ranges of HCBD concentration in 595 food samples were as follows: not detectable (nd)-0.947 ng/g for agricultural products, nd-0.920 ng/g for animal products, nd-1.323 ng/g for fishery products and nd-1.081 ng/g for processed food products. The daily intakes of HCBD for the general population were 0.22 ng/kg body weight (b.w.)/day for agricultural products, 0.30 ng/kg b.w./day for animal products, 0.07 ng/kg b.w./day for fishery products and 0.33 ng/kg b.w./day for processed food products. These exposure levels are below the tolerable daily intake (TDI, 2 μg/kg body weight/day) established by the National Institute of Food and Drug Safety Evaluation (NiFDS) in the Republic of Korea. Taking into account the risk index of 0.011%, we can, therefore, conclude that there are no health concerns for the Korean population.
ISSN:1944-0049
1944-0057
DOI:10.1080/19440049.2022.2146210