Loading…
A pH-responsive T 1 -T 2 dual-modal MRI contrast agent for cancer imaging
Magnetic resonance imaging (MRI) is a non-invasive imaging technology to diagnose health conditions, showing the weakness of low sensitivity. Herein, we synthesize a contrast agent, SPIO@SiO @MnO , which shows decreased T and T contrast intensity in normal physiological conditions. In the acid envir...
Saved in:
Published in: | Nature communications 2022-12, Vol.13 (1), p.7948 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Magnetic resonance imaging (MRI) is a non-invasive imaging technology to diagnose health conditions, showing the weakness of low sensitivity. Herein, we synthesize a contrast agent, SPIO@SiO
@MnO
, which shows decreased T
and T
contrast intensity in normal physiological conditions. In the acid environment of tumor or inflamed tissue, the manganese dioxide (MnO
) layer decomposes into magnetically active Mn
(T
-weighted), and the T
and T
signals are sequentially recovered. In addition, both constrast quenching-activation degrees of T
and T
images can be accurately regulated by the silicon dioxide (SiO
) intermediate layer between superparamagnetic iron oxide (SPIO) and MnO
. Through the "dual-contrast enhanced subtraction" imaging processing technique, the contrast sensitivity of this MRI contrast agent is enhanced to a 12.3-time difference between diseased and normal tissue. Consequently, SPIO@SiO
@MnO
is successfully applied to trace the tiny liver metastases of approximately 0.5 mm and monitor tissue inflammation. |
---|---|
ISSN: | 2041-1723 |