Levels of bioavailable, and free forms of 25(OH)D after supplementation with vitamin D 3 in primary hyperparathyroidism

The 25 hydroxyvitamin D [25(OH)D] is the major metabolite for ascertaining vitamin D status, which circulates bound to a specific carrier (vitamin D-binding protein - VDBP). A portion that circulates unbound vary according to the VDBP genotype. This study evaluates the behavior of different forms of...

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Published in:Endocrine 2023-04, Vol.80 (1), p.183
Main Authors: Dos Santos, Lívia Marcela, Ohe, Monique Nakayama, Pallone, Sthefanie Giovanna, Nacaguma, Isabela Ohki, Kunii, Ilda Sizue, da Silva, Renata Elen Costa, Maeda, Sergio Setsuo, Vieira, José Gilberto Henriques, Lazaretti-Castro, Marise
Format: Article
Language:English
Subjects:
Cholecalciferol - therapeutic use
Dietary Supplements
Humans
Hyperparathyroidism, Primary - drug therapy
Vitamin D
Vitamin D-Binding Protein - genetics
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Summary:The 25 hydroxyvitamin D [25(OH)D] is the major metabolite for ascertaining vitamin D status, which circulates bound to a specific carrier (vitamin D-binding protein - VDBP). A portion that circulates unbound vary according to the VDBP genotype. This study evaluates the behavior of different forms of 25(OH)D, before and after supplementation with 14,000 IU of vitamin D3, weekly for 12 weeks, in individuals with primary hyperparathyroidism and controls. Fifty-six patients with active primary hyperparathyroidism (PHPT) and 64 paired controls (CTRL), not taking vitamin D3 for the last three months, were enrolled. The genetic isotypes of VDBP were determined to calculate bioavailable and free 25(OH)D. A p 
ISSN:1559-0100