Placental F 4 -Neuroprostanes and F 2 -Isoprostanes are altered in gestational diabetes mellitus and maternal obesity

We investigated whether gestational diabetes mellitus (GDM) associated with maternal obesity modifies the placental profile of F -Neuroprostanes and F -Isoprostanes, metabolites of non-enzymatic oxidation of docosahexaenoic acid (DHA) and arachidonic acid (AA), respectively. Twenty-five placental sa...

Full description

Saved in:
Bibliographic Details
Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2023-02, Vol.189, p.102529
Main Authors: Ferreira, Carolina S, Pinto, Gabriela D A, Reis, Desirée L, Vigor, Claire, Goes, Vanessa A, Guimarães, Deborah de A B, Mucci, Daniela B, Belcastro, Livia, Saraiva, Marcelle A, Oger, Camille, Galano, Jean-Marie, Sardinha, Fátima L C, Torres, Alexandre G, Durand, Thierry, Burton, Graham J, El-Bacha, Tatiana
Format: Article
Language:English
Subjects:
Arachidonic Acid - metabolism
Diabetes, Gestational - metabolism
Docosahexaenoic Acids - metabolism
F2-Isoprostanes - metabolism
Female
Humans
Isoprostanes
Neuroprostanes - metabolism
Obesity - metabolism
Obesity, Maternal - metabolism
Placenta - metabolism
Pregnancy
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated whether gestational diabetes mellitus (GDM) associated with maternal obesity modifies the placental profile of F -Neuroprostanes and F -Isoprostanes, metabolites of non-enzymatic oxidation of docosahexaenoic acid (DHA) and arachidonic acid (AA), respectively. Twenty-five placental samples were divided into lean (n=11), obesity (n=7) and overweight/obesity+GDM (n=7) groups. F -Neuroprostanes and F -Isoprostanes were higher in obesity compared to lean controls, but reduced to levels similar to lean women when obesity is further complicated with GDM. Lower content of F -Isoprostanes suggests adaptive placental responses in GDM attenuating oxidative stress. However, low levels of placental F -Neuroprostanes may indicate impaired DHA metabolism in GDM, affecting fetal development and offspring health. These results were not related to differences in placental content of DHA, AA and polyunsaturated fatty acids status nor to maternal diet or gestational weight gain. Placental DHA and AA metabolism differs in obesity and GDM, highlighting the importance of investigating the signalling roles of F -Neuroprostanes and F -Isoprostanes in the human term placenta.
ISSN:1532-2823
DOI:10.1016/j.plefa.2022.102529