Terminalia catappa attenuates phenylhydrazine-induced anaemia and hepato-renal toxicity in male Wistar rat by boosting blood cells, modulation of lipoproteins and up-regulation of in vivo antioxidant armouries

This study investigated the haematinic, antihyperlipidaemic, hepato-renal protective effects of Terminalia catappa aqueous leaf extract on male Wistar rats exposed to phenylhydrazine toxicity. Animals were exposed to phenylhydrazine (PHZ) 50 mg/kg intraperitoneal for two consecutive days thereafter,...

Full description

Saved in:
Bibliographic Details
Published in:Biomarkers 2023-04, Vol.28 (3), p.302-312
Main Authors: Umoren, Elizabeth, Asiwe, Jerome Ndudi, Okon, Idara Asuquo, Levi Amangieka, Albert, Nyenke, Clement U., Nnamudi, Anthony Chibuzor, Modo, Emmanuel U., Bassey, Augustine I. L., Nwikue, Gospel, Etim, Okon E.
Format: Article
Language:English
Subjects:
Anemia
Animals
antioxidants
Antioxidants - pharmacology
Blood Cells
hyperlipidaemia
Lipoproteins - pharmacology
Liver
liver enzymes
Male
Plant Extracts - pharmacology
Rats
Rats, Wistar
renal function
Terminalia
Terminalia catappa
Up-Regulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study investigated the haematinic, antihyperlipidaemic, hepato-renal protective effects of Terminalia catappa aqueous leaf extract on male Wistar rats exposed to phenylhydrazine toxicity. Animals were exposed to phenylhydrazine (PHZ) 50 mg/kg intraperitoneal for two consecutive days thereafter, treated with T. catappa extract (100 mg/kg and 200 mg/kg) orally for 21 days. After the experimentation, animals were sedated with ketamine (70 mg/kg) and euthanized by cervical dislodgement. Blood and organs were collected for haematology and biochemical studies following standard laboratory methods. Our study showed that T. catappa significantly increased erythrocytes, haemoglobin, haematocrit and high density lipoprotein as well as down-regulating leukocytes, thrombocytes, ALP AST, ALT creatinine, urea, total cholesterol as well as low density lipoprotein. The liver, kidney and spleen antioxidant defence were also up-regulated against the adverse effect caused by phenylhydrazine exposure. Terminalia catappa attenuated Phenylhydrazine-induced anaemia and hepato-renal toxicity in male Wistar rat by boosting blood cells, modulation of lipoproteins and up-regulation of in vivo antioxidant armouries.
ISSN:1354-750X
1366-5804
DOI:10.1080/1354750X.2023.2166588