Impact of N-heteroaromatic N-termini in Cu() ATCUN metallopeptides on their biorelevant redox activity

Cu( ii ) complexes with ATCUN peptide ligands have been investigated for their ROS (reactive oxygen species) generation and oxidative DNA degradation abilities. The biological activity of most ATCUN complexes such as Cu-GGH (Gly-Gly-His) is, however, low. Tuning the redox chemistry by incorporation...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2023-03, Vol.52 (11), p.3279-3286
Main Authors: Barrera, Jannis, Haeri, Haleh, Heinrich, Julian, Stein, Matthias, Hinderberger, Dariush, Kulak, Nora
Format: Article
Language:English
Subjects:
Biological activity
Copper
Copper - chemistry
Oxidation-Reduction
Peptides
Reactive Oxygen Species
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Summary:Cu( ii ) complexes with ATCUN peptide ligands have been investigated for their ROS (reactive oxygen species) generation and oxidative DNA degradation abilities. The biological activity of most ATCUN complexes such as Cu-GGH (Gly-Gly-His) is, however, low. Tuning the redox chemistry by incorporation of N-heteroaromatics reinstates ROS production which leads to efficient DNA cleavage. Incorporation of artificial N-donor molecules into Cu( ii ) ATCUN peptides leads to efficient ROS generation and oxidative DNA degradation.
ISSN:1477-9226
1477-9234
DOI:10.1039/d2dt02044k