Investigating Neutrophil-to-Lymphocyte and C-Reactive Protein-to-Albumin Ratios in Type 2 Diabetic Patients with Dry Eye Disease

• Published in: Ocular immunology and inflammation 2024-07, Vol.ahead-of-print (ahead-of-print), p.1-7
• Main Authors: Alhalwani, Amani Y., Baqar, Rawan, Algadaani, Rawan, Bamallem, Hala, Alamoudi, Rwzan, Jambi, Shatha, Abd El Razek Mady, Wessam, Sannan, Naif S., Anwar Khan, Muhammed
• Format: Article
• Language: English
• Subjects: C-reactive protein-to-albumin ratio; dry-eye disease; neutrophil-to-lymphocyte ratio; type 2 diabetes; type 2 diabetes with dry-eye disease
• ISSN: 0927-3948; 1744-5078; 1744-5078
• DOI: 10.1080/09273948.2022.2152698

Patients with Diabetes mellitus (DM) are at risk of developing dry eye disease (DED). We investigated routine laboratory parameters in patients with type 2 DM (T2D) and T2D-DED to identify potential inflammatory markers. A retrospective study of 241 randomly selected patients (30 DED non-diabetic, 120 T2D, and 91 with T2D-DED). The neutrophil-to-lymphocyte ratios (NLR), CRP-to-albumin ratios (CAR), and the glycosylated haemoglobin A1c (HbA1c) results were correlated between groups. The NLR and HbA1c were significantly higher in the T2D-DED group (p≤0.001 and 0.0001, respectively) when compared with T2D and DED non-diabetic groups. CAR was insignificantly high in the three groups (p=0.192). A positive correlation was identified between CAR and NLR in T2D-DED patients (p= 0.008).                        In T2D-DED patients, NLR was significantly high and positively correlate with CAR. These results predicate diabetes with dry eye complications, and biomarker-mediated inflammation may have important roles in DED pathogenesis.