Peliminary exploration on the differential diagnosis between meningioma and schwannoma using contrast-enhanced T 1 WI flow-sensitive black-blood sequence

Contrast-enhanced T WI flow-sensitive black-blood (CE-T1WI FSBB) is a newly developed sequence which had not been widely used for differential diagnosis of brain tumors. To quantify the pre-operative imaging features of intratumoral microbleeds and intratumoral vessels using CE-T WI FSBB scan and st...

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Published in:Frontiers in oncology 2022, Vol.12, p.1006190
Main Authors: Cao, Xin, Lv, Kun, Xu, Siting, Feng, Zhe, Yin, Xuyang, Pan, Lei, Geng, Daoying, Zhang, Jun
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Lv, Kun
Xu, Siting
Feng, Zhe
Yin, Xuyang
Pan, Lei
Geng, Daoying
Zhang, Jun
description Contrast-enhanced T WI flow-sensitive black-blood (CE-T1WI FSBB) is a newly developed sequence which had not been widely used for differential diagnosis of brain tumors. To quantify the pre-operative imaging features of intratumoral microbleeds and intratumoral vessels using CE-T WI FSBB scan and study the differences in biological behavior of meningiomas and schwannomas underlying the imaging features. Seventy-three cases of meningiomas and 24 cases of schwannomas confirmed by postoperative pathology were included. Two neuroradiologists independently counted intratumoral vessels and intratumoral microbleeds based on CE-T WI FSBB images. The vessel density index (VDI) and microbleed density index (MDI) were the number of intratumoral vessels and the number of intratumoral microbleeds divided by the tumor volume, respectively. The consistency test of intratumoral vessel count and intratumoral microbleed count based on CE-T WI FSBB were summarized using 2-way random intraclass correlation coefficients (ICC). Mann-Whitney U-test and chi-square test were used to determine significant differences between meningiomas and schwannomas, and fibrous meningiomas and epithelial meningiomas.
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To quantify the pre-operative imaging features of intratumoral microbleeds and intratumoral vessels using CE-T WI FSBB scan and study the differences in biological behavior of meningiomas and schwannomas underlying the imaging features. Seventy-three cases of meningiomas and 24 cases of schwannomas confirmed by postoperative pathology were included. Two neuroradiologists independently counted intratumoral vessels and intratumoral microbleeds based on CE-T WI FSBB images. The vessel density index (VDI) and microbleed density index (MDI) were the number of intratumoral vessels and the number of intratumoral microbleeds divided by the tumor volume, respectively. The consistency test of intratumoral vessel count and intratumoral microbleed count based on CE-T WI FSBB were summarized using 2-way random intraclass correlation coefficients (ICC). Mann-Whitney U-test and chi-square test were used to determine significant differences between meningiomas and schwannomas, and fibrous meningiomas and epithelial meningiomas. <0.05 was considered statistically significant. The ICC of intratumoral vessels count and intratumoral microbleeds count were 0.89 and 0.99, respectively. There were significant differences in the number of intratumoral microbleeds ( <0.01) and MDI values ( <0.01) between meningiomas and schwannomas. There were no differences in the number of intratumoral vessels ( =0.64), VDI ( =0.17), or tumor volume ( =0.33). There were also differences in the number of intratumoral microbleeds ( <0.01), the MDI value ( <0.01), and the sex of patients ( <0.05) between fibrous meningiomas and epithelial meningiomas. CE-T WI FSBB can be a new technique for differentiating schwannomas from meningiomas, and even different types of meningiomas. 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To quantify the pre-operative imaging features of intratumoral microbleeds and intratumoral vessels using CE-T WI FSBB scan and study the differences in biological behavior of meningiomas and schwannomas underlying the imaging features. Seventy-three cases of meningiomas and 24 cases of schwannomas confirmed by postoperative pathology were included. Two neuroradiologists independently counted intratumoral vessels and intratumoral microbleeds based on CE-T WI FSBB images. The vessel density index (VDI) and microbleed density index (MDI) were the number of intratumoral vessels and the number of intratumoral microbleeds divided by the tumor volume, respectively. The consistency test of intratumoral vessel count and intratumoral microbleed count based on CE-T WI FSBB were summarized using 2-way random intraclass correlation coefficients (ICC). Mann-Whitney U-test and chi-square test were used to determine significant differences between meningiomas and schwannomas, and fibrous meningiomas and epithelial meningiomas. <0.05 was considered statistically significant. The ICC of intratumoral vessels count and intratumoral microbleeds count were 0.89 and 0.99, respectively. There were significant differences in the number of intratumoral microbleeds ( <0.01) and MDI values ( <0.01) between meningiomas and schwannomas. There were no differences in the number of intratumoral vessels ( =0.64), VDI ( =0.17), or tumor volume ( =0.33). There were also differences in the number of intratumoral microbleeds ( <0.01), the MDI value ( <0.01), and the sex of patients ( <0.05) between fibrous meningiomas and epithelial meningiomas. CE-T WI FSBB can be a new technique for differentiating schwannomas from meningiomas, and even different types of meningiomas. 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To quantify the pre-operative imaging features of intratumoral microbleeds and intratumoral vessels using CE-T WI FSBB scan and study the differences in biological behavior of meningiomas and schwannomas underlying the imaging features. Seventy-three cases of meningiomas and 24 cases of schwannomas confirmed by postoperative pathology were included. Two neuroradiologists independently counted intratumoral vessels and intratumoral microbleeds based on CE-T WI FSBB images. The vessel density index (VDI) and microbleed density index (MDI) were the number of intratumoral vessels and the number of intratumoral microbleeds divided by the tumor volume, respectively. The consistency test of intratumoral vessel count and intratumoral microbleed count based on CE-T WI FSBB were summarized using 2-way random intraclass correlation coefficients (ICC). Mann-Whitney U-test and chi-square test were used to determine significant differences between meningiomas and schwannomas, and fibrous meningiomas and epithelial meningiomas. <0.05 was considered statistically significant. The ICC of intratumoral vessels count and intratumoral microbleeds count were 0.89 and 0.99, respectively. There were significant differences in the number of intratumoral microbleeds ( <0.01) and MDI values ( <0.01) between meningiomas and schwannomas. There were no differences in the number of intratumoral vessels ( =0.64), VDI ( =0.17), or tumor volume ( =0.33). There were also differences in the number of intratumoral microbleeds ( <0.01), the MDI value ( <0.01), and the sex of patients ( <0.05) between fibrous meningiomas and epithelial meningiomas. CE-T WI FSBB can be a new technique for differentiating schwannomas from meningiomas, and even different types of meningiomas. 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title Peliminary exploration on the differential diagnosis between meningioma and schwannoma using contrast-enhanced T 1 WI flow-sensitive black-blood sequence
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