Static first-minute-frame (FMF) PET imaging after 18 F-labeled amyloid tracer injection is correlated to [ 18 F]FDG PET in patients with primary progressive aphasia

• Published in: Revista Española de medicina nuclear e imagen molecular (English ed.) 2023-07, Vol.42 (4), p.211
• Main Authors: Gómez-Grande, Adolfo, Seiffert, Alexander P, Villarejo-Galende, Alberto, González-Sánchez, Marta, Llamas-Velasco, Sara, Bueno, Héctor, Gómez, Enrique J, Tabuenca, María José, Sánchez-González, Patricia
• Format: Article
• Language: English
• ISSN: 2253-8089
• DOI: 10.1016/j.remnie.2023.02.001

To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with F-labeled amyloid-binding radiotracers and brain [ F]FDG PET in patients with primary progressive aphasia (PPA). The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9 nonfluent variant PPA, 4 logopenic variant PPA, 1 semantic variant PPA, 3 unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [ F]FDG PET images and Pearson's correlation coefficients are calculated. SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of r=0.94±0.06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images. The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.