Immune mechanisms of group B coxsackievirus induced viral myocarditis

Viral myocarditis is known to be a primary cause of dilated cardiomyopathy (DCM) that can lead to heart failure and sudden cardiac death and is invariably caused by myocardial viral infection following active inflammatory destruction of the myocardium. Although acute viral myocarditis frequently rec...

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Bibliographic Details
Published in:Virulence 2023-12, Vol.14 (1), p.2180951-2180951
Main Authors: Zhang, Yue, Zhou, Xiaobin, Chen, Shuyi, Sun, Xinchen, Zhou, Chenglin
Format: Article
Language:English
Subjects:
adaptive immunity
Animals
Coxsackievirus Infections
Disease Models, Animal
Enterovirus B, Human
Heart
innate immunity
Mice
Myocarditis
Myocardium
pattern recognition receptors (PRRs)
Review
Reviews
T lymphocytes
Viral myocarditis
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Summary:Viral myocarditis is known to be a primary cause of dilated cardiomyopathy (DCM) that can lead to heart failure and sudden cardiac death and is invariably caused by myocardial viral infection following active inflammatory destruction of the myocardium. Although acute viral myocarditis frequently recovers on its own, current chronic myocarditis therapies are unsatisfactory, where the persistence of viral or immunological insults to the heart may play a role. Cellular and mouse experimental models that utilized the most prevalent Coxsackievirus group B type 3 (CVB3) virus infection causing myocarditis have illustrated the pathophysiology of viral myocarditis. In this review, immunological insights into the different stages of development of viral myocarditis were discussed, concentrating on the mechanisms of innate and adaptive immunity in the development of CVB3-induced myocarditis.
ISSN:2150-5594
2150-5608
DOI:10.1080/21505594.2023.2180951