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CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD 2
The number of people suffering from hair loss is increasing, and hair loss occurs not only in older men but also in women and young people. Prostaglandin D (PGD ) is a well-known alopecia inducer. However, the mechanism by which PGD induces alopecia is poorly understood. In this study, we characteri...
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| Published in: | Cells (Basel, Switzerland) Switzerland), 2023-02, Vol.12 (4) |
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| Main Authors: | , , , , , , , , , , |
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| Language: | English |
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| container_title | Cells (Basel, Switzerland) |
| container_volume | 12 |
| creator | Ryu, Yeong Chan Park, Jiyeon Kim, You-Rin Choi, Sehee Kim, Geon-Uk Kim, Eunhwan Hwang, Yumi Kim, Heejene Han, Gyoonhee Lee, Soung-Hoon Choi, Kang-Yell |
| description | The number of people suffering from hair loss is increasing, and hair loss occurs not only in older men but also in women and young people. Prostaglandin D
(PGD
) is a well-known alopecia inducer. However, the mechanism by which PGD
induces alopecia is poorly understood. In this study, we characterized CXXC5, a negative regulator of the Wnt/β-catenin pathway, as a mediator for hair loss by PGD
. The hair loss by PGD
was restored by
knock-out or treatment of protein transduction domain-Dishevelled binding motif (PTD-DBM), a peptide activating the Wnt/β-catenin pathway via interference with the Dishevelled (Dvl) binding function of CXXC5. In addition, suppression of neogenic hair growth by PGD
was also overcome by PTD-DBM treatment or
knock-out as shown by the wound-induced hair neogenesis (WIHN) model. Moreover, we found that CXXC5 also mediates DHT-induced hair loss via PGD
. DHT-induced hair loss was alleviated by inhibition of both GSK-3β and CXXC5 functions. Overall, CXXC5 mediates the hair loss by the DHT-PGD
axis through suppression of Wnt/β-catenin signaling. |
| doi_str_mv | 10.3390/cells12040555 |
| format | article |
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(PGD
) is a well-known alopecia inducer. However, the mechanism by which PGD
induces alopecia is poorly understood. In this study, we characterized CXXC5, a negative regulator of the Wnt/β-catenin pathway, as a mediator for hair loss by PGD
. The hair loss by PGD
was restored by
knock-out or treatment of protein transduction domain-Dishevelled binding motif (PTD-DBM), a peptide activating the Wnt/β-catenin pathway via interference with the Dishevelled (Dvl) binding function of CXXC5. In addition, suppression of neogenic hair growth by PGD
was also overcome by PTD-DBM treatment or
knock-out as shown by the wound-induced hair neogenesis (WIHN) model. Moreover, we found that CXXC5 also mediates DHT-induced hair loss via PGD
. DHT-induced hair loss was alleviated by inhibition of both GSK-3β and CXXC5 functions. Overall, CXXC5 mediates the hair loss by the DHT-PGD
axis through suppression of Wnt/β-catenin signaling.</description><identifier>EISSN: 2073-4409</identifier><identifier>DOI: 10.3390/cells12040555</identifier><identifier>PMID: 36831222</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Adolescent ; Aged ; Alopecia ; beta Catenin - metabolism ; DNA-Binding Proteins ; Female ; Glycogen Synthase Kinase 3 beta ; Hair - metabolism ; Humans ; Male ; Preimplantation Diagnosis ; Transcription Factors</subject><ispartof>Cells (Basel, Switzerland), 2023-02, Vol.12 (4)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-9270-5408 ; 0000-0003-2983-3252 ; 0000-0002-0952-3276</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36831222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryu, Yeong Chan</creatorcontrib><creatorcontrib>Park, Jiyeon</creatorcontrib><creatorcontrib>Kim, You-Rin</creatorcontrib><creatorcontrib>Choi, Sehee</creatorcontrib><creatorcontrib>Kim, Geon-Uk</creatorcontrib><creatorcontrib>Kim, Eunhwan</creatorcontrib><creatorcontrib>Hwang, Yumi</creatorcontrib><creatorcontrib>Kim, Heejene</creatorcontrib><creatorcontrib>Han, Gyoonhee</creatorcontrib><creatorcontrib>Lee, Soung-Hoon</creatorcontrib><creatorcontrib>Choi, Kang-Yell</creatorcontrib><title>CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD 2</title><title>Cells (Basel, Switzerland)</title><addtitle>Cells</addtitle><description>The number of people suffering from hair loss is increasing, and hair loss occurs not only in older men but also in women and young people. Prostaglandin D
(PGD
) is a well-known alopecia inducer. However, the mechanism by which PGD
induces alopecia is poorly understood. In this study, we characterized CXXC5, a negative regulator of the Wnt/β-catenin pathway, as a mediator for hair loss by PGD
. The hair loss by PGD
was restored by
knock-out or treatment of protein transduction domain-Dishevelled binding motif (PTD-DBM), a peptide activating the Wnt/β-catenin pathway via interference with the Dishevelled (Dvl) binding function of CXXC5. In addition, suppression of neogenic hair growth by PGD
was also overcome by PTD-DBM treatment or
knock-out as shown by the wound-induced hair neogenesis (WIHN) model. Moreover, we found that CXXC5 also mediates DHT-induced hair loss via PGD
. DHT-induced hair loss was alleviated by inhibition of both GSK-3β and CXXC5 functions. Overall, CXXC5 mediates the hair loss by the DHT-PGD
axis through suppression of Wnt/β-catenin signaling.</description><subject>Adolescent</subject><subject>Aged</subject><subject>Alopecia</subject><subject>beta Catenin - metabolism</subject><subject>DNA-Binding Proteins</subject><subject>Female</subject><subject>Glycogen Synthase Kinase 3 beta</subject><subject>Hair - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Preimplantation Diagnosis</subject><subject>Transcription Factors</subject><issn>2073-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpjYBA1NNAzNrY00E9OzckpNjQyMDEwNTVlYuA0MjA31jUxMbDkYOAtLs4yAAILQzNDA1N2Bg5jMwtjQyMjI04GK-eICGdTBd_UlMzEktRiBRePEF3PvJTS5NQUBce8lKL89NS81JLMZAXHnPyC1OTMRIUyIA5wd1Ew4mFgTUvMKU7lhdLcDHJuriHOHroFpUm5qSnxBUWZuYlFlfEwy4wJKgAAuu83uQ</recordid><startdate>20230209</startdate><enddate>20230209</enddate><creator>Ryu, Yeong Chan</creator><creator>Park, Jiyeon</creator><creator>Kim, You-Rin</creator><creator>Choi, Sehee</creator><creator>Kim, Geon-Uk</creator><creator>Kim, Eunhwan</creator><creator>Hwang, Yumi</creator><creator>Kim, Heejene</creator><creator>Han, Gyoonhee</creator><creator>Lee, Soung-Hoon</creator><creator>Choi, Kang-Yell</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0002-9270-5408</orcidid><orcidid>https://orcid.org/0000-0003-2983-3252</orcidid><orcidid>https://orcid.org/0000-0002-0952-3276</orcidid></search><sort><creationdate>20230209</creationdate><title>CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD 2</title><author>Ryu, Yeong Chan ; Park, Jiyeon ; Kim, You-Rin ; Choi, Sehee ; Kim, Geon-Uk ; Kim, Eunhwan ; Hwang, Yumi ; Kim, Heejene ; Han, Gyoonhee ; Lee, Soung-Hoon ; Choi, Kang-Yell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_368312223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Aged</topic><topic>Alopecia</topic><topic>beta Catenin - metabolism</topic><topic>DNA-Binding Proteins</topic><topic>Female</topic><topic>Glycogen Synthase Kinase 3 beta</topic><topic>Hair - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Preimplantation Diagnosis</topic><topic>Transcription Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ryu, Yeong Chan</creatorcontrib><creatorcontrib>Park, Jiyeon</creatorcontrib><creatorcontrib>Kim, You-Rin</creatorcontrib><creatorcontrib>Choi, Sehee</creatorcontrib><creatorcontrib>Kim, Geon-Uk</creatorcontrib><creatorcontrib>Kim, Eunhwan</creatorcontrib><creatorcontrib>Hwang, Yumi</creatorcontrib><creatorcontrib>Kim, Heejene</creatorcontrib><creatorcontrib>Han, Gyoonhee</creatorcontrib><creatorcontrib>Lee, Soung-Hoon</creatorcontrib><creatorcontrib>Choi, Kang-Yell</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cells (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryu, Yeong Chan</au><au>Park, Jiyeon</au><au>Kim, You-Rin</au><au>Choi, Sehee</au><au>Kim, Geon-Uk</au><au>Kim, Eunhwan</au><au>Hwang, Yumi</au><au>Kim, Heejene</au><au>Han, Gyoonhee</au><au>Lee, Soung-Hoon</au><au>Choi, Kang-Yell</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD 2</atitle><jtitle>Cells (Basel, Switzerland)</jtitle><addtitle>Cells</addtitle><date>2023-02-09</date><risdate>2023</risdate><volume>12</volume><issue>4</issue><eissn>2073-4409</eissn><abstract>The number of people suffering from hair loss is increasing, and hair loss occurs not only in older men but also in women and young people. Prostaglandin D
(PGD
) is a well-known alopecia inducer. However, the mechanism by which PGD
induces alopecia is poorly understood. In this study, we characterized CXXC5, a negative regulator of the Wnt/β-catenin pathway, as a mediator for hair loss by PGD
. The hair loss by PGD
was restored by
knock-out or treatment of protein transduction domain-Dishevelled binding motif (PTD-DBM), a peptide activating the Wnt/β-catenin pathway via interference with the Dishevelled (Dvl) binding function of CXXC5. In addition, suppression of neogenic hair growth by PGD
was also overcome by PTD-DBM treatment or
knock-out as shown by the wound-induced hair neogenesis (WIHN) model. Moreover, we found that CXXC5 also mediates DHT-induced hair loss via PGD
. DHT-induced hair loss was alleviated by inhibition of both GSK-3β and CXXC5 functions. Overall, CXXC5 mediates the hair loss by the DHT-PGD
axis through suppression of Wnt/β-catenin signaling.</abstract><cop>Switzerland</cop><pmid>36831222</pmid><doi>10.3390/cells12040555</doi><orcidid>https://orcid.org/0000-0002-9270-5408</orcidid><orcidid>https://orcid.org/0000-0003-2983-3252</orcidid><orcidid>https://orcid.org/0000-0002-0952-3276</orcidid></addata></record> |
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| ispartof | Cells (Basel, Switzerland), 2023-02, Vol.12 (4) |
| issn | 2073-4409 |
| language | eng |
| recordid | cdi_pubmed_primary_36831222 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Adolescent Aged Alopecia beta Catenin - metabolism DNA-Binding Proteins Female Glycogen Synthase Kinase 3 beta Hair - metabolism Humans Male Preimplantation Diagnosis Transcription Factors |
| title | CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD 2 |
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