Causes of Mutation Rate Variability in Plant Genomes

Mutation is the source of all heritable diversity, the essential material of evolution and breeding. While mutation rates are often regarded as constant, variability in mutation rates has been observed at nearly every level-varying across mutation types, genome locations, gene functions, epigenomic...

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Bibliographic Details
Published in:Annual review of plant biology 2023-05, Vol.74 (1), p.751-775
Main Authors: Quiroz, Daniela, Lensink, Mariele, Kliebenstein, Daniel J, Monroe, J. Grey
Format: Article
Language:English
Subjects:
chromatin
Deoxyribonucleic acid
DNA
DNA damage
DNA repair
DNA Transposable Elements - genetics
Environmental conditions
Evolution, Molecular
Genome, Plant
Genomes
Genotypes
Mutation
Mutation Rate
Mutation rates
Plant Breeding
plant evolution
Plants - genetics
Variability
Variation
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Summary:Mutation is the source of all heritable diversity, the essential material of evolution and breeding. While mutation rates are often regarded as constant, variability in mutation rates has been observed at nearly every level-varying across mutation types, genome locations, gene functions, epigenomic contexts, environmental conditions, genotypes, and species. This mutation rate variation arises from differential rates of DNA damage, repair, and transposable element activation and insertion that together produce what is measured by DNA mutation rates. We review historical and recent investigations into the causes and consequences of mutation rate variability in plants by focusing on the mechanisms shaping this variation. Emerging mechanistic models point to the evolvability of mutation rate variation across genomes via mechanisms that target DNA repair, shaping the diversification of plants at phenotypic and genomic scales.
ISSN:1543-5008
1545-2123
DOI:10.1146/annurev-arplant-070522-054109