Chryroxosides A-E: five new triterpene saponins from the leaves of Chrysophyllum roxburghii G.Don. and their cytotoxic activity

Five undescribed oleanane triterpene glycosides named chryroxosides A-D (1-5), together with five known compounds (6-10) were isolated from the leaves of Chrysophyllum roxburghii G.Don. Their chemical structures were elucidated by extensive spectroscopic data analyses including IR, HR-ESI-MS, 1D and...

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Bibliographic Details
Published in:Natural product research 2024-03, Vol.38 (5), p.735-743
Main Authors: Hang, Pham Thi, Hue, Nguyen Thi, Nam, Nguyen Hoang, Tuan, Nguyen Le, Van Cuong, Pham, Vuong, Nguyen Quoc, Hoang, Nguyen Huy, Tai, Bui Huu, Kiem, Phan Van
Format: Article
Language:English
Subjects:
Cell lines
chryroxoside
Chrysophyllum
Chrysophyllum roxburghii
cytotoxic evaluation
Cytotoxicity
Glycosides
NMR
Nuclear magnetic resonance
Saponins
Sapotaceae
Triterpene saponins
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Summary:Five undescribed oleanane triterpene glycosides named chryroxosides A-D (1-5), together with five known compounds (6-10) were isolated from the leaves of Chrysophyllum roxburghii G.Don. Their chemical structures were elucidated by extensive spectroscopic data analyses including IR, HR-ESI-MS, 1D and 2D NMR). Compounds 1, 3, and 5 showed cytotoxic effects against KB, HepG2, HL60, P388, HT29, and MCF7 cell lines with the IC 50 values ranging from 14.40 to 52.63 μM compared to the positive control compound (ellipticine) with the IC 50 values ranging from 1.34 to 1.99 μM.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2023.2196623