Predictive Impact of Prognostic Nutritional Index in Patients with Cancer Treated with Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis

A few previous studies have investigated the prognostic value of the prognostic nutritional index (PNI) in patients treated with immune checkpoint inhibitors (ICIs); however, the results are inconsistent. Therefore, this study aimed to clarify the prognostic significance of PNI. The PubMed, Embase,...

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Bibliographic Details
Published in:Nutrition and cancer 2023, Vol.75 (6), p.1413-1426
Main Authors: Xu, Xin-Tian, Qian, Yu, Tian, Meng-Xing, Ding, Chen-Chen, Guo, Huan, Tang, Jing, Pi, Guo-Liang, Wu, Yuan, Dai, Zhu, Jin, Xin
Format: Article
Language:English
Subjects:
Disease control
Immune checkpoint inhibitors
Impact analysis
Impact prediction
Inhibitors
Meta-analysis
Nutrition assessment
Subgroups
Survival
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Summary:A few previous studies have investigated the prognostic value of the prognostic nutritional index (PNI) in patients treated with immune checkpoint inhibitors (ICIs); however, the results are inconsistent. Therefore, this study aimed to clarify the prognostic significance of PNI. The PubMed, Embase, and Cochrane Library databases were searched. A meta-analysis of the impact of PNI on overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and rate of adverse events (AEs) in patients treated with ICIs was performed. Twenty-three studies involving 2,386 patients were included. Low PNI was associated with significantly poor OS (hazard ratio [HR] = 2.26, 95% confidence interval [CI]: 1.81-2.82, P 
ISSN:0163-5581
1532-7914
DOI:10.1080/01635581.2023.2203355