Antimicrobial metabolites produced by endophytic fungi associated with the leaves of Vochysia divergens

Investigation of the endophytic fungi Nigrospora sphaerica, Nigrospora oryzae, and Pseudofusicoccum stromaticum MeOH fractions isolated from the leaves of Vochysia divergens, a medicinal species from the Brazilian Pantanal, led to the identification of five compounds, namely a new compound (1E,8Z)-1...

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Bibliographic Details
Published in:Natural product research 2024-03, Vol.38 (6), p.978-985
Main Authors: Souza, Jéssica A. de M., Gubiani, Juliana R., de Siqueira, Kátia A., de Camargo, Maria J., Garcez, Walmir S., de Sousa, Paulo T., Soares, Marcos A., Araújo, Ângela R., Nunes, Emanuel V. dos S., Vieira, Lucas C. C., Sampaio, Olívia M., Goulart, Letícia S., Biasetto, Carolina R., de Menezes, Orivaldo T., de Oliveira, Camila M., Nogueira, Cláudio R., Pinto, Luciano da S., Teles, Helder L.
Format: Article
Language:English
Subjects:
antibacterial activity
Antibacterial agents
Antiinfectives and antibacterials
Antimicrobial activity
Divergence
Endophytes
Endophytic fungi
Fungi
Mass spectrometry
Mass spectroscopy
Metabolites
Microorganisms
Opportunist infection
Vochysia divergens
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Summary:Investigation of the endophytic fungi Nigrospora sphaerica, Nigrospora oryzae, and Pseudofusicoccum stromaticum MeOH fractions isolated from the leaves of Vochysia divergens, a medicinal species from the Brazilian Pantanal, led to the identification of five compounds, namely a new compound (1E,8Z)-10,11-dihydroxy-5,5,8-trimethyl-4-oxocycloundeca-1,8-diene-1-carbaldehyde (1) and four known compounds: 5-methylmellein (2), sclerone (3), daldinone A (4), and lasiodiplodin (5). All compounds were identified using spectroscopic methods, and 1 was corroborated with mass spectrometry, while the known compounds were compared with data in the literature. The relative configuration of compound 1 was determined based on theoretical conformational studies as well as the J experimental values between the hydroxymethyne hydrogens. The antimicrobial activity of the compounds was evaluated. Promising results were obtained for compounds 2, 4, and 5 since they inhibited the bacterium Pseudomonas aeruginosa, an opportunistic pathogen, suggesting the potential of these microorganisms as a source of new antibacterial agents.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2023.2208723