Effects of fluorescein on corneal endothelial morphology after fundus fluorescein angiography in patients with diabetic macular edema

To evaluate the effects of fluorescein dye on corneal endothelial morphology (CEM) after fundus fluorescein angiography (FFA) in patients with diabetic macular edema (DME). In this retrospective study, patients were divided into two groups, nonproliferative diabetic retinopathy (Group-1, NPDR) and p...

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Published in:Cutaneous and ocular toxicology 2023-09, Vol.ahead-of-print (ahead-of-print), p.1-6
Main Authors: Limon, Utku, Özsoy Saygın, Işılay, Gezginaslan, Tuğba Aydoğan, Bozkurt, Erdinç, Bulut, Sinan, Ilkay Sezgin Akçay, Betül
Format: Article
Language:English
Subjects:
corneal endothelial morphology
Diabetes Mellitus
diabetic macular edema
Diabetic Retinopathy - diagnostic imaging
Fluorescein
Fluorescein Angiography
Fluorescein dye
Humans
Macular Edema - diagnostic imaging
Retrospective Studies
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Summary:To evaluate the effects of fluorescein dye on corneal endothelial morphology (CEM) after fundus fluorescein angiography (FFA) in patients with diabetic macular edema (DME). In this retrospective study, patients were divided into two groups, nonproliferative diabetic retinopathy (Group-1, NPDR) and proliferative diabetic retinopathy (Group-2, PDR). CEM properties including endothelial cell density (ECD), coefficient of variation of cell area (CV), average cell area (AVG), percentage of hexagonal cells (HEX), and central corneal thickness (CCT) were measured before FFA and at week 1 and month 1 after FFA were collected from patients' charts. The study consisted of 48 patient's 48 eyes in Group-1 and 50 patient's 50 eyes in Group-2. In both groups, the mean ECD, CV, AVG, HEX, and CCT measurements at week 1 and month 1 after FFA did not differ statistically from the mean measurements before FFA (p > 0.05). The mean ECD measurements in Group-1 were higher than that in Group-2 and showed statistically significant differences among the groups (p  0.05). In Group-2 there was no statistically significant relationship between BCVA, IOP, and CMT measurements and ECD, AVG, CV, HEX, and CCT measurements before FFA, at week 1 and month 1 after FFA (p > 0.05). There is no significant change in CEM after FFA in patients with NPDR and PDR with DME.
ISSN:1556-9527
1556-9535
DOI:10.1080/15569527.2023.2215346