Evaluation of new biomarkers in stage III and IV endometriosis

To investigate the efficacy of new endometriosis biomarkers in diagnosis and treatment. Thirty women with Stage III-IV endometriosis who were given an indication for surgery and 49 control patients were compared. Preoperative and postoperative serum levels of Annexin A5 (ANXA5), soluble intercellula...

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Published in:Gynecological endocrinology 2023-12, Vol.39 (1), p.2217290-2217290
Main Authors: Kovalak, Evrim Ebru, Karacan, Tolga, Zengi, Oğuzhan, Karabay Akgül, Özlem, Özyürek, Şefik Eser, Güraslan, Hakan
Format: Article
Language:English
Subjects:
angiogenesis
biomarker
Biomarkers - blood
CA-125 Antigen
Case-Control Studies
cytokines
Cytokines - blood
diagnostic markers
Endometriosis
Endometriosis - metabolism
Female
Humans
Interleukin-6
noninvasive
Tumor Necrosis Factor-alpha - metabolism
Vascular Cell Adhesion Molecule-1
Vascular Endothelial Growth Factor A
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Summary:To investigate the efficacy of new endometriosis biomarkers in diagnosis and treatment. Thirty women with Stage III-IV endometriosis who were given an indication for surgery and 49 control patients were compared. Preoperative and postoperative serum levels of Annexin A5 (ANXA5), soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), soluble vascular cell adhesion molecule-1 (sVCAM-1), vascular endothelial growth factors (VEGF) and Ca-125 measurements were compared. AUCs of ANXA5, sICAM-1, IL-6, TNF-α, VCAM-1, VEGF biomarkers were not found to be significant in diagnosing endometriosis when evaluated alone (p > 0.05). Only the AUC of the Ca-125 biomarker values were found to be significant with 73% sensitivity and 98% specificity (p 
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2023.2217290