Recent Advances in 64 Cu/ 67 Cu-Based Radiopharmaceuticals

Copper-64 (T = 12.7 h) is a positron and beta-emitting isotope, with decay characteristics suitable for both positron emission tomography (PET) imaging and radiotherapy of cancer. Copper-67 (T = 61.8 h) is a beta and gamma emitter, appropriate for radiotherapy β-energy and with a half-life suitable...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2023-05, Vol.24 (11)
Main Authors: Krasnovskaya, Olga O, Abramchuck, Daniil, Erofeev, Alexander, Gorelkin, Peter, Kuznetsov, Alexander, Shemukhin, Andrey, Beloglazkina, Elena K
Format: Article
Language:English
Subjects:
Copper
Humans
Neoplasms - diagnostic imaging
Neoplasms - radiotherapy
Positron-Emission Tomography - methods
Radiopharmaceuticals - chemistry
Tomography, Emission-Computed, Single-Photon
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Copper-64 (T = 12.7 h) is a positron and beta-emitting isotope, with decay characteristics suitable for both positron emission tomography (PET) imaging and radiotherapy of cancer. Copper-67 (T = 61.8 h) is a beta and gamma emitter, appropriate for radiotherapy β-energy and with a half-life suitable for single-photon emission computed tomography (SPECT) imaging. The chemical identities of Cu and Cu isotopes allow for convenient use of the same chelating molecules for sequential PET imaging and radiotherapy. A recent breakthrough in Cu production opened previously unavailable opportunities for a reliable source of Cu with high specific activity and purity. These new opportunities have reignited interest in the use of copper-containing radiopharmaceuticals for the therapy, diagnosis, and theranostics of various diseases. Herein, we summarize recent (2018-2023) advances in the use of copper-based radiopharmaceuticals for PET, SPECT imaging, radiotherapy, and radioimmunotherapy.
ISSN:1422-0067
DOI:10.3390/ijms24119154