Two new norcassane-type diterpenoids from Mezonevron sinense Hemsl

Two new norcassane-type diterpenoids, named 6β-hydroxy-bisnorcass-13-en-12-one (1) and 6β-hydroxy-bisnorcassan-12-one (2), were isolated from the seeds of Mezonevron sinense Hemsl. The structures of compounds 1-2 were determined by extensive spectroscopic analysis. Two compounds exhibited immunosupp...

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Published in:Natural product research 2024-09, Vol.ahead-of-print (ahead-of-print), p.1-6
Main Authors: Su, Jie-Xia, Gu, Wen-Jian, Chen, Yuan-Kai, Zhang, Pu-Zhao, Zhang, Ya-Mei
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - drug effects
Concanavalin A
Diterpenes
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
immunosuppressive activity
Immunosuppressive agents
Immunosuppressive Agents - chemistry
Immunosuppressive Agents - isolation & purification
Immunosuppressive Agents - pharmacology
Lymphocytes
Lymphocytes T
Mezonevron sinense
Molecular Structure
norcassane-type diterpenoids
Seeds - chemistry
T-Lymphocytes - drug effects
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Summary:Two new norcassane-type diterpenoids, named 6β-hydroxy-bisnorcass-13-en-12-one (1) and 6β-hydroxy-bisnorcassan-12-one (2), were isolated from the seeds of Mezonevron sinense Hemsl. The structures of compounds 1-2 were determined by extensive spectroscopic analysis. Two compounds exhibited immunosuppressive activity with the IC 50 values of 19.35 ± 0.87 μM and 18.69 ± 0.88 μM in the ConA induced T cell model and 65.04 ± 0.83 μM and 48.06 ± 0.76 μM in LPS induced B cell model, respectively.
ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2023.2219821