Multiple clonal transmissions of clinically relevant ESBL- Escherichia coli between livestock, dogs, and wildlife in Chile

Extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) are a main cause of human deaths associated with antimicrobial resistance (AMR). Despite hundreds of reports of the faecal carriage of ESBL-E. coli in domestic and wild animals, the dynamics of its circulation remains poorly...

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Bibliographic Details
Published in:Journal of global antimicrobial resistance. 2023-07
Main Authors: Hayer, Juliette, Salgado-Caxito, Marília, Opazo-Capurro, Andrés, Muñoz, Paulina González, Millán, Javier, Piñeiro, Ana, Munita, Jose, Rivas, Lina, Benavides, Julio
Format: Article
Language:English
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Summary:Extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) are a main cause of human deaths associated with antimicrobial resistance (AMR). Despite hundreds of reports of the faecal carriage of ESBL-E. coli in domestic and wild animals, the dynamics of its circulation remains poorly understood. We used whole genome sequencing of 19 ESBL-E. coli previously isolated in the same local setting from dogs, livestock, and a wild rodent in Central Chile to assess potential cross-species transmission of ESBL-E. coli. Isolates harboured a large number of AMR (n=95) and virulence (n=45) genes, plasmids replicons (n=24) and E. coli Sequence Types including top extraintestinal pathogenic E. coli ST410, ST58, ST88, and ST617. Almost identical clones (
ISSN:2213-7173
DOI:10.1016/j.jgar.2023.07.009