Mitochondrial NIR imaging probe mitigating oxidative damage by targeting HDAC6

Despite the apparent copious fluorescent probes targeting mitochondria, the development of low cytotoxic probes is still needed for improving validation of mitochondrial function assessment. Herein, we report a novel cyanine-based NIR fluorescent probe, T2 , which selectively targets mitochondria wi...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-08, Vol.59 (67), p.119-1112
Main Authors: Kim, Jungryun, Jangili, Paramesh, Kim, Jeongah, Lucia, Stephani Edwina, Ryu, Jae Ryun, Prasad, Renuka, Zi, Soyu, Kim, Pilhan, Sun, Woong, Kim, Jong Seung
Format: Article
Language:English
Subjects:
Cell death
Fluorescent indicators
Homeostasis
Mitochondria
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Summary:Despite the apparent copious fluorescent probes targeting mitochondria, the development of low cytotoxic probes is still needed for improving validation of mitochondrial function assessment. Herein, we report a novel cyanine-based NIR fluorescent probe, T2 , which selectively targets mitochondria with significantly low toxicity by modulating the intracellular redox status. Additionally, T2 inhibits oxidative stress-induced cell death in cortical neurons. This study provides new insight into developing low-toxic mitochondrial imaging agents by regulating redox homeostasis. Despite the apparent copious fluorescent probes targeting mitochondria, the development of low cytotoxic probes is still needed. We have newly developed a novel NIR mitochondrial probe that exhibits low toxicity.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc03259k