Ketamine: Mechanisms and Relevance to Treatment of Depression

Major depressive disorder (MDD) is a leading cause of suicide in the world. Monoamine-based antidepressant drugs are a primary line of treatment for this mental disorder, although the delayed response and incomplete efficacy in some patients highlight the need for improved therapeutic approaches. Ov...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of medicine 2024-01, Vol.75 (1), p.129-143
Main Authors: Kim, Ji-Woon, Suzuki, Kanzo, Kavalali, Ege T, Monteggia, Lisa M
Format: Article
Language:English
Subjects:
Amines - therapeutic use
antidepressant
Antidepressive Agents - therapeutic use
Delayed response
Depression - drug therapy
Depressive Disorder, Major - drug therapy
hippocampus
Humans
Ketamine
Ketamine - therapeutic use
major depressive disorder
Mental depression
NMDA receptor
Patients
Suicide
synaptic plasticity
treatment-resistant depression
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Major depressive disorder (MDD) is a leading cause of suicide in the world. Monoamine-based antidepressant drugs are a primary line of treatment for this mental disorder, although the delayed response and incomplete efficacy in some patients highlight the need for improved therapeutic approaches. Over the past two decades, ketamine has shown rapid onset with sustained (up to several days) antidepressant effects in patients whose MDD has not responded to conventional antidepressant drugs. Recent preclinical studies have started to elucidate the underlying mechanisms of ketamine's antidepressant properties. Herein, we describe and compare recent clinical and preclinical findings to provide a broad perspective of the relevant mechanisms for the antidepressant action of ketamine.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev-med-051322-120608