Clinical Utility of Flow Cytometry for Detection of Anti-Jk b IgM in Acute Haemolytic Transfusion Reaction

Acute hemolytic transfusion reaction (AHTR) is a rare but life-threatening complication of transfusion. We herein report a case of anti-Jk IgM-related AHTR. Two hours after an 80-year-old man with myelodysplastic syndrome received a packed red blood cell (RBC) A /Rh /Jk c transfusion, he developed a...

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Bibliographic Details
Published in:Internal medicine (Tokyo, 1992) 1992), 2024-05, Vol.63 (9), p.1273
Main Authors: Nagaharu, Keiki, Izumi, Takuya, Maruyama, Mitsuko, Sugimoto, Yuka, Ohishi, Kohshi, Tawara, Isao, Usui, Eiji, Tamaki, Shigehisa
Format: Article
Language:English
Subjects:
Acute Disease
Aged, 80 and over
Erythrocyte Transfusion - adverse effects
Flow Cytometry
Humans
Immunoglobulin M - blood
Male
Myelodysplastic Syndromes - blood
Myelodysplastic Syndromes - diagnosis
Myelodysplastic Syndromes - immunology
Myelodysplastic Syndromes - therapy
Transfusion Reaction - blood
Transfusion Reaction - diagnosis
Transfusion Reaction - immunology
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Summary:Acute hemolytic transfusion reaction (AHTR) is a rare but life-threatening complication of transfusion. We herein report a case of anti-Jk IgM-related AHTR. Two hours after an 80-year-old man with myelodysplastic syndrome received a packed red blood cell (RBC) A /Rh /Jk c transfusion, he developed acute respiratory failure and a fever. Although he had tested negative in routine screening tests, the 37°C normal saline test was weakly positive for Jk . We confirmed the presence of anti-Jk IgM in the patient's serum by flow cytometry. This case demonstrates the potential utility of flow cytometry for IgM detection.
ISSN:1349-7235
DOI:10.2169/internalmedicine.2639-23