Fabrication of poly (lactic-co-glycolic acid)/gelatin electro spun nanofiber patch containing CaCO 3 /SiO 2 nanocomposite and quercetin for accelerated diabetic wound healing

An open wound or sore on the bottom of the foot caused by diabetes is known as a diabetic foot ulcer. Preventive measures are essential, including consistent foot care and glycemic management. The dangers associated with diabetic foot ulcers can be reduced via early identification and timely treatme...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-01, Vol.254 (Pt 3), p.128060
Main Authors: Kumar, Ajay S, Prema, D, Rao, R Gagana, Prakash, J, Balashanmugam, P, Devasena, T, Venkatasubbu, G Devanand
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - therapeutic use
Diabetes Mellitus - drug therapy
Diabetic Foot - drug therapy
Gelatin
Glycols
Humans
Nanocomposites
Nanofibers
Quercetin - pharmacology
Silicon Dioxide
Wound Healing
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Summary:An open wound or sore on the bottom of the foot caused by diabetes is known as a diabetic foot ulcer. Preventive measures are essential, including consistent foot care and glycemic management. The dangers associated with diabetic foot ulcers can be reduced via early identification and timely treatment. The risk of foot ulcers and limb amputation increases with age and duration of diabetes. Quercetin contains anti-inflammatory and antioxidant properties. Furthermore, the calcium carbonate/silica (CaCO /SiO ) nanocomposite has a good anti-inflammatory property due to the presence of calcium, which will aid in wound healing. As a result, combining quercetin (plant based anti-inflammatory drug) and CaCO3/SiO2 nanocomposite will boost the wound healing rate. We have synthesized CaCO /SiO nanocomposite in sol-gel method and characterized using XRD, FTIR and TEM. Cell line tests and the MTT assay revealed that the PLGA/gelatin/CaCO /SiO /quercetin patch enhanced the proliferation of cells. Its anti-bacterial efficacy against four major bacterial strains often found in wound locations, as well as its water retention, make it an ideal material for diabetic wound healing. In-vivo trials confirms the enhanced diabetic wound healing potential of the patch.
ISSN:1879-0003
DOI:10.1016/j.ijbiomac.2023.128060