UV/H 2 O 2 -Degraded Polysaccharides from Sargassum fusiforme : Purification, Structural Properties, and Anti-Inflammatory Activity

The main purpose of this study was to analyze the structural properties and anti-inflammatory activity of the purified fractions derived from UV/H O -degraded polysaccharides from . Results indicated that twofractions with different monosaccharide compositions and morphological characteristics, PT-0...

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Bibliographic Details
Published in:Marine drugs 2023-10, Vol.21 (11)
Main Authors: Chang, Shiyuan, Chen, Xiaoyong, Chen, Yifan, You, Lijun, Hileuskaya, Kseniya
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents
Hydrogen Peroxide - metabolism
Hydrogen Peroxide - pharmacology
Polysaccharides - chemistry
Sargassum - chemistry
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Summary:The main purpose of this study was to analyze the structural properties and anti-inflammatory activity of the purified fractions derived from UV/H O -degraded polysaccharides from . Results indicated that twofractions with different monosaccharide compositions and morphological characteristics, PT-0.25 (yield 39.5%) and PT-0.5 (yield 23.9%), were obtained. The average molecular weights of PT-0.25 and PT-0.5 were 14.52 kDa and 22.89 kDa, respectively. In addition, PT-0.5 exhibited better anti-inflammatory activity with a clear dose dependence. The mechanism was associated with the inhibition of LPS-activated Toll-like receptor 4-mediated inflammatory pathways in RAW264.7 cells. The results showed that PT-0.5 was a complex polysaccharide mainly composed of 4-Fuc , t-Man , 6-Gal , t-Fuc , and 3,4-GlcA . These results would provide theoretical support for studying the structural properties and biological activities of UV/H O -degraded polysaccharides.
ISSN:1660-3397
DOI:10.3390/md21110561