New Application of cyclo Saligenyl Prodrugs Approach for the Delivery of Fosfoxacin Derivatives in Mycobacteria

In this work, we implemented for the first time the Saligenyl prodrug strategy to increase the bioavailability of fosmidomycin phosphate analogs in bacteria. Here, we report the synthesis of 34 Saligenyl prodrugs of fosfoxacin and its derivatives. Among them, fifteen double prodrugs efficiently prev...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-11, Vol.28 (23)
Main Authors: Munier, Mathilde, Tritsch, Denis, Lièvremont, Didier, Rohmer, Michel, Grosdemange-Billiard, Catherine
Format: Article
Language:English
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Summary:In this work, we implemented for the first time the Saligenyl prodrug strategy to increase the bioavailability of fosmidomycin phosphate analogs in bacteria. Here, we report the synthesis of 34 Saligenyl prodrugs of fosfoxacin and its derivatives. Among them, fifteen double prodrugs efficiently prevented the growth of the non-pathogenic, fast-growing .
ISSN:1420-3049