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Gabapentinoids in Ireland 2010 to 2020: an observational study of trends in gabapentinoid prescribing, law enforcement drug seizures and post mortem toxicology

We explored trends in gabapentinoid prescribing, drug seizures and post mortem toxicology using a national pharmacy claims database, law enforcement drug seizures data and a population based post mortem toxicology database. Gabapentinoid prescribing rates per 100,000 eligible population (2010-2020),...

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Bibliographic Details
Published in:British journal of clinical pharmacology 2023-12
Main Authors: Durand, Louise, O'Kane, Aoife, Tierney, Julie, Cronly, Mark, Bennett, Kathleen E, Kavanagh, Yvonne, Keenan, Eamon, Cousins, Gráinne
Format: Article
Language:English
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Summary:We explored trends in gabapentinoid prescribing, drug seizures and post mortem toxicology using a national pharmacy claims database, law enforcement drug seizures data and a population based post mortem toxicology database. Gabapentinoid prescribing rates per 100,000 eligible population (2010-2020), annual number of drug seizures involving gabapentinoids (2012-2020), and gabapentinoid detection (positive) rates per 100 post mortem toxicology case (2013-2020) were calculated. Negative binomial regression models were used to evaluate longitudinal trends for gabapentin and pregabalin separately. Gabapentin (Adjusted Rate Ratio (ARR) 1.06, 95% CI 1.05-1.06, p
ISSN:1365-2125