The Added-on of Ziziphus jujube Syrup in the Treatment of Chronic Spontaneous Urticaria Resistant to Standard-Dose of Secondary-generation H 1 Antihistamine: A Double-Blind Randomized Clinical Trial

Although antihistamines are the first-line treatment for chronic spontaneous urticaria (CSU), 50% of patients don't respond to standard doses. In this study, the effectiveness of fruit syrup in combination with antihistamines was assessed in patients with CSU. This double-blind randomized clini...

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Published in:Iranian journal of medical sciences 2023-11, Vol.48 (6), p.582
Main Authors: Zare, Hamid, Nabavizdeh, Seyed Hesamedin, Jaladat, Amir Mohamad, Zarshenas, Mohamad Mehdi, Moghtaderi, Mozhgan, Basirat, Atefeh, Nasri, Nahid
Format: Article
Language:English
Subjects:
Chronic Disease
Chronic Urticaria - drug therapy
Histamine H1 Antagonists - pharmacology
Histamine H1 Antagonists - therapeutic use
Humans
Urticaria - drug therapy
Ziziphus
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Summary:Although antihistamines are the first-line treatment for chronic spontaneous urticaria (CSU), 50% of patients don't respond to standard doses. In this study, the effectiveness of fruit syrup in combination with antihistamines was assessed in patients with CSU. This double-blind randomized clinical trial was conducted in Shiraz between December 2019 and December 2020. 64 patients with CSU who had experienced hives for at least six weeks and did not respond to the usual treatments were enrolled in the study. They were randomly assigned to intervention and control groups using permuted block random allocation. For four weeks, the intervention group received 7.5 mL syrup twice a day, while the control group received 7.5 mL simple jujube syrup twice a day. Both groups received cetirizine 10 mg every night. Urticaria activity score (UAS) and CU-Q oL questionnaires were used to assess urticaria state and sleep quality before and after each week for four consecutive weeks. Data were analyzed using SPSS software version 18, and P
ISSN:1735-3688
DOI:10.30476/IJMS.2023.95531.2690