Relationship between ETCO 2 and PaCO 2 under Changing Capnogram in Ventilated Infants with NAVA: An Observational Study

This observational study evaluated the validity of end-tidal CO (ETCO ) as a surrogate for arterial PCO (PaCO ) in infants on neurally adjusted ventilatory assist (NAVA), particularly considering the influence of variable spontaneous breathing on capnography waveforms. The study involved 16 infants,...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of pediatrics 2024-10, Vol.91 (10), p.1072
Main Authors: Takahashi, Daijiro, Goto, Koko, Goto, Kei
Format: Article
Language:English
Subjects:
Blood Gas Analysis
Capnography - methods
Carbon Dioxide - blood
Female
Humans
Infant
Infant, Newborn
Interactive Ventilatory Support - methods
Male
Respiration, Artificial
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 10
container_start_page 1072
container_title Indian journal of pediatrics
container_volume 91
creator Takahashi, Daijiro
Goto, Koko
Goto, Kei
description This observational study evaluated the validity of end-tidal CO (ETCO ) as a surrogate for arterial PCO (PaCO ) in infants on neurally adjusted ventilatory assist (NAVA), particularly considering the influence of variable spontaneous breathing on capnography waveforms. The study involved 16 infants, analyzing 50 paired ETCO and PaCO values. Deming regression analysis highlighted a notably stronger correlation for maximum ETCO (r  = 0.6783, p 
doi_str_mv 10.1007/s12098-023-04976-0
format article
fullrecord <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_38133873</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>38133873</sourcerecordid><originalsourceid>FETCH-pubmed_primary_381338733</originalsourceid><addsrcrecordid>eNqFjs1KxDAUhYMgzvjzAi7kvkD0tpGmcVeKohtHVGY7pOROG2nvlCS1zNs7DLp2dc7i8H1HiOsMbzNEfRezHE0pMVcS740uJJ6IJRqtpC6MWojzGL8Qc4OFORMLVWZKlVotxfxOvU1-x7HzIzSUZiKGx896BTlYdvBmj3ViRwHqznLruYXajrxrgx3AM6yJkz9QyMELby2nCLNPHbxW6-oBKoZVEyl8HzW2h480uf2lON3aPtLVb16Im6eD9VmOUzOQ24zBDzbsN39P1b-DHylXTgM</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Relationship between ETCO 2 and PaCO 2 under Changing Capnogram in Ventilated Infants with NAVA: An Observational Study</title><source>Springer Link</source><creator>Takahashi, Daijiro ; Goto, Koko ; Goto, Kei</creator><creatorcontrib>Takahashi, Daijiro ; Goto, Koko ; Goto, Kei</creatorcontrib><description>This observational study evaluated the validity of end-tidal CO (ETCO ) as a surrogate for arterial PCO (PaCO ) in infants on neurally adjusted ventilatory assist (NAVA), particularly considering the influence of variable spontaneous breathing on capnography waveforms. The study involved 16 infants, analyzing 50 paired ETCO and PaCO values. Deming regression analysis highlighted a notably stronger correlation for maximum ETCO (r  = 0.6783, p &lt;0.0001) compared to mean ETCO (r  = 0.5686, p &lt;0.0001) and demonstrated a significantly weaker association for minimum ETCO (r  = 0.1838). These findings emphasize the superior predictive value of maximum ETCO in estimating PaCO , advocating its reliable use in clinical monitoring, especially given the dynamic capnography associated with NAVA's variable pressures. The results suggest ETCO 's potential to enhance noninvasive respiratory management, reduce the frequency of blood sampling, and improve overall care for infants requiring mechanical ventilation.</description><identifier>EISSN: 0973-7693</identifier><identifier>DOI: 10.1007/s12098-023-04976-0</identifier><identifier>PMID: 38133873</identifier><language>eng</language><publisher>India</publisher><subject>Blood Gas Analysis ; Capnography - methods ; Carbon Dioxide - blood ; Female ; Humans ; Infant ; Infant, Newborn ; Interactive Ventilatory Support - methods ; Male ; Respiration, Artificial</subject><ispartof>Indian journal of pediatrics, 2024-10, Vol.91 (10), p.1072</ispartof><rights>2023. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-0921-3240</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38133873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahashi, Daijiro</creatorcontrib><creatorcontrib>Goto, Koko</creatorcontrib><creatorcontrib>Goto, Kei</creatorcontrib><title>Relationship between ETCO 2 and PaCO 2 under Changing Capnogram in Ventilated Infants with NAVA: An Observational Study</title><title>Indian journal of pediatrics</title><addtitle>Indian J Pediatr</addtitle><description>This observational study evaluated the validity of end-tidal CO (ETCO ) as a surrogate for arterial PCO (PaCO ) in infants on neurally adjusted ventilatory assist (NAVA), particularly considering the influence of variable spontaneous breathing on capnography waveforms. The study involved 16 infants, analyzing 50 paired ETCO and PaCO values. Deming regression analysis highlighted a notably stronger correlation for maximum ETCO (r  = 0.6783, p &lt;0.0001) compared to mean ETCO (r  = 0.5686, p &lt;0.0001) and demonstrated a significantly weaker association for minimum ETCO (r  = 0.1838). These findings emphasize the superior predictive value of maximum ETCO in estimating PaCO , advocating its reliable use in clinical monitoring, especially given the dynamic capnography associated with NAVA's variable pressures. The results suggest ETCO 's potential to enhance noninvasive respiratory management, reduce the frequency of blood sampling, and improve overall care for infants requiring mechanical ventilation.</description><subject>Blood Gas Analysis</subject><subject>Capnography - methods</subject><subject>Carbon Dioxide - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Interactive Ventilatory Support - methods</subject><subject>Male</subject><subject>Respiration, Artificial</subject><issn>0973-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFjs1KxDAUhYMgzvjzAi7kvkD0tpGmcVeKohtHVGY7pOROG2nvlCS1zNs7DLp2dc7i8H1HiOsMbzNEfRezHE0pMVcS740uJJ6IJRqtpC6MWojzGL8Qc4OFORMLVWZKlVotxfxOvU1-x7HzIzSUZiKGx896BTlYdvBmj3ViRwHqznLruYXajrxrgx3AM6yJkz9QyMELby2nCLNPHbxW6-oBKoZVEyl8HzW2h480uf2lON3aPtLVb16Im6eD9VmOUzOQ24zBDzbsN39P1b-DHylXTgM</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Takahashi, Daijiro</creator><creator>Goto, Koko</creator><creator>Goto, Kei</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0003-0921-3240</orcidid></search><sort><creationdate>202410</creationdate><title>Relationship between ETCO 2 and PaCO 2 under Changing Capnogram in Ventilated Infants with NAVA: An Observational Study</title><author>Takahashi, Daijiro ; Goto, Koko ; Goto, Kei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_381338733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Blood Gas Analysis</topic><topic>Capnography - methods</topic><topic>Carbon Dioxide - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Interactive Ventilatory Support - methods</topic><topic>Male</topic><topic>Respiration, Artificial</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Daijiro</creatorcontrib><creatorcontrib>Goto, Koko</creatorcontrib><creatorcontrib>Goto, Kei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Indian journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Daijiro</au><au>Goto, Koko</au><au>Goto, Kei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between ETCO 2 and PaCO 2 under Changing Capnogram in Ventilated Infants with NAVA: An Observational Study</atitle><jtitle>Indian journal of pediatrics</jtitle><addtitle>Indian J Pediatr</addtitle><date>2024-10</date><risdate>2024</risdate><volume>91</volume><issue>10</issue><spage>1072</spage><pages>1072-</pages><eissn>0973-7693</eissn><abstract>This observational study evaluated the validity of end-tidal CO (ETCO ) as a surrogate for arterial PCO (PaCO ) in infants on neurally adjusted ventilatory assist (NAVA), particularly considering the influence of variable spontaneous breathing on capnography waveforms. The study involved 16 infants, analyzing 50 paired ETCO and PaCO values. Deming regression analysis highlighted a notably stronger correlation for maximum ETCO (r  = 0.6783, p &lt;0.0001) compared to mean ETCO (r  = 0.5686, p &lt;0.0001) and demonstrated a significantly weaker association for minimum ETCO (r  = 0.1838). These findings emphasize the superior predictive value of maximum ETCO in estimating PaCO , advocating its reliable use in clinical monitoring, especially given the dynamic capnography associated with NAVA's variable pressures. The results suggest ETCO 's potential to enhance noninvasive respiratory management, reduce the frequency of blood sampling, and improve overall care for infants requiring mechanical ventilation.</abstract><cop>India</cop><pmid>38133873</pmid><doi>10.1007/s12098-023-04976-0</doi><orcidid>https://orcid.org/0000-0003-0921-3240</orcidid></addata></record>
fulltext fulltext
identifier EISSN: 0973-7693
ispartof Indian journal of pediatrics, 2024-10, Vol.91 (10), p.1072
issn 0973-7693
language eng
recordid cdi_pubmed_primary_38133873
source Springer Link
subjects Blood Gas Analysis
Capnography - methods
Carbon Dioxide - blood
Female
Humans
Infant
Infant, Newborn
Interactive Ventilatory Support - methods
Male
Respiration, Artificial
title Relationship between ETCO 2 and PaCO 2 under Changing Capnogram in Ventilated Infants with NAVA: An Observational Study
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T13%3A18%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20between%20ETCO%202%20and%20PaCO%202%20under%20Changing%20Capnogram%20in%20Ventilated%20Infants%20with%20NAVA:%20An%20Observational%20Study&rft.jtitle=Indian%20journal%20of%20pediatrics&rft.au=Takahashi,%20Daijiro&rft.date=2024-10&rft.volume=91&rft.issue=10&rft.spage=1072&rft.pages=1072-&rft.eissn=0973-7693&rft_id=info:doi/10.1007/s12098-023-04976-0&rft_dat=%3Cpubmed%3E38133873%3C/pubmed%3E%3Cgrp_id%3Ecdi_FETCH-pubmed_primary_381338733%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/38133873&rfr_iscdi=true