Solvent-controlled halohydroxylation or C3-C2 coupling of pyridinium salts through an interrupted dearomative reduction

Herein, we report an efficient and easily operable method to halohydroxylate pyridiniums through an interrupted dearomative reduction strategy. In this process, we make the most of the halide anion from the pyridinium salts by performing the reaction in DMSO without the need of external HX added. No...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-01, Vol.6 (8), p.992-995
Main Authors: Zhang, Congcong, Chen, Qinhao, Qin, Yunlong, Bu, Zhanwei, Wang, Qilin
Format: Article
Language:English
Subjects:
Coupling
Reduction
Solvents
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Summary:Herein, we report an efficient and easily operable method to halohydroxylate pyridiniums through an interrupted dearomative reduction strategy. In this process, we make the most of the halide anion from the pyridinium salts by performing the reaction in DMSO without the need of external HX added. Notably, by changing the solvents from DMSO into Et 2 O, the bimolecular C3-C2 coupling occurs successfully. Herein, we report a solvent-controlled halohydroxylation or C3-C2 coupling of pyridinium salts through an interrupted dearomative reduction.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc05212e